氨甲环酸在全髋关节置换围手术期的应用  

Application of tranexamic acid in perioperative period of total hip arthroplasty

作　　者：许德慧[1] 

机构地区：[1]吉林油田总医院骨科,138000

出　　处：《中国现代药物应用》2016年第13期3-4,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨氨甲环酸在全髋关节置换(THA)围手术期应用的临床效果。方法 65例行THA患者,随机分为治疗组33例与对照组32例。治疗组患者在开皮前将氨甲环酸1 g溶于100 ml生理盐水中静脉滴注,术后临时夹闭引流管3 h,术后3 h重复上述方法应用氨甲环酸1次;对照组不给予止血药物,术后正常引流。比较两组术中出血量、术后引流量及手术总失血量,观察血栓相关并发症的发生情况。结果治疗组术中出血量、切口引流量及手术总失血量均少于对照组,差异均具有统计学意义(P<0.05);术后两组无血栓栓塞等并发症发生。结论 THA围手术期使用氨甲环酸能有效减少手术失血量,临床效果满意。Objective To investigate clinical effect by tranexamic acid applied in perioperative period of total hip arthroplasty （THA）. Methods A total of 65 THA patients were randomly divided into treatment group with 33 cases and control group with 32 cases. The treatment group received 1 g tranexamic acid with 100 ml normal saline by intravenous drip before operation, followed by temporary drainage tube closure for 3 h after operation and then repeated administration of tranexamic acid. The control group received no hemostasis drug, along with normal drainage after operation. Comparison was made on intraoperative bleeding volume, postoperative drainage volume and total bleeding volume between the two groups, and observation was made on thrombus-related complications. Results The treatment group had all less intraoperative bleeding volume, incision drainage volume and total bleeding volume than the control group, and their differences all had statistical significance （P〈0.05）. No thromboemholism as complications occurred in the two groups. Conclusion Application of tranexamic acid in perioperative period of THA can precisely reduce bleeding volume in operation, along with satisfactory clinical effect.

关 键 词：氨甲环酸 全髋关节置换 围手术期 应用 

分 类 号：R687.4[医药卫生—骨科学]