丹参注射液联合贝那普利治疗Ⅳ期糖尿病肾病疗效观察  

Clinical observation combination of Benazepril and Danshen injection in the treatment of stage Ⅳ diabetic nephropathy

作　　者：胡波[1] 王燕舞[2] 马广骏[1] 杜昱蕾[2] 窦静[2] 

机构地区：[1]解放军260医院,河北石家庄050041 [2]白求恩医务士官学校,河北石家庄050081

出　　处：《现代中西医结合杂志》2016年第23期2519-2521,2609,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：全军青年培育项目(13QNP187)

摘　　要：目的观察丹参注射液联合贝那普利治疗Ⅳ期糖尿病肾病患者的临床疗效。方法将552例Ⅳ期糖尿病肾病患者随机分为对照组、贝那普利组、丹参联合贝那普利组各184例,3组均给予胰岛素和/或降糖药物及口服双氢克尿噻片治疗,贝那普利组同时给予贝那普利10 mg/d口服,丹参联合贝那普利组在贝那普利组治疗基础上给予丹参注射液400mg/d静滴,连续4周。检测治疗前后血压、血糖、糖化血红蛋白(Hb A1c)、D-二聚体、纤维蛋白原(FIB)、同型半胱氨酸(Hcy)、总胆固醇(TC)、三酰甘油(TG)、尿液AQP2、血肌酐(SCr)、24 h尿蛋白定量及肾小球滤过率(GFR)。结果治疗前3组各项指标比较差异均无统计学意义(P均>0.05)。治疗后贝那普利组、丹参联合贝那普利组血压、SCr、24 h尿蛋白定量、TC、TG、D-二聚体、FIB、Hcy均明显降低(P均<0.05),GFR、尿AQP2均明显升高(P均<0.05),且各指标改善情况均明显优于对照组(P均<0.05);丹参联合贝那普利组治疗后SCr、24 h尿蛋白定量、TC、TG、D-二聚体、FIB、Hcy均明显低于贝那普利组(P均<0.05),而GFR、尿AQP2均明显高于贝那普利组(P均<0.05)。结论丹参注射液联合贝那普利治疗Ⅳ期糖尿病肾病效果更好,可明显提高GFR及尿AQP2水平,降低24 h尿蛋白定量、SCr、TC、TG、D-二聚体、FIB、Hcy水平。Objective It is to observe the clinical effect of combination of Danshen injection on stage Ⅳdiabetic nephrop-athy.Methods Five hundred and fifty-two patients with stage Ⅳ diabetic nephropathy were randomly divided into 3 groups：control group, Benazepril group, Benazepril＋Danshen injection group （combination group）, each group had 184 cases.All the patients were treated with insulin with or without hypoglycemic agents and hydrochlorothiazide by oral administration . Benazepril group was given Renazepril 10 mg/d orally, the combination group was added with Danshen injection 400 mgd/by intravenous drip additionally on the basis of treatment in Benazepril group .All the groups were treated for 4weeks.Blood pressure, plasma glucose ,HbAlc, D-dimer, fibrinogen （FIB）, homocysteine （Hcy）, total cholesterol（TC）, Triglyceride （TG）, urine AQP2, serum creatinine（SCr）,urine protein and glomerular filtration rate （GFR） were measured respectively before and after treatment .Results There was no significant difference in the indexes above before treatment among every group.After treatment, the levels of blood pressure,SCr and urine protein, D-dime,FIB,Hcy,TC,TG were obviously de-creased and the levels of GFR , urine AQP2 were increased significantly in Benazepril group and combination group （ P 〈0.05 ） ,and the improvements were all better than those in control group .The levels of blood pressure , urine protein , D-dime, FIB, Hcy, TC, TG and SCr were much lower and the level of GFR ,urine AQP2 after treatment was higher in combina-tion group than those in Benazepril group .Conclusion Combination of Benazepril and Danshen injection had good curative effect on diabetic nephropathy , which could enhance GFR and urine AQP 2, decrease the levels of urine protein , D-dime, FIB, Hcy,TC,TG and SCr in the patients with diabetic nephropathy .

关 键 词：丹参注射液 贝那普利 糖尿病肾病 肾小球滤过率 尿AQP2 

分 类 号：R587.1[医药卫生—内分泌]