pH/温度双重响应抗肿瘤药物微球的制备和研究  

Preparation and application of pH/temperature double-responsive polymer microspheres on delivery of anti-tumor drugs

作　　者：朱颖[1] 

机构地区：[1]天津医科大学第二医院药学部,天津300211

出　　处：《天津医科大学学报》2016年第4期354-358,共5页Journal of Tianjin Medical University

摘　　要：目的:制备能够在人体正常生理温度及肿瘤细胞内部酸性环境中,可实现p H/温度双重刺激响应性控制释药的抗肿瘤药物微球。方法:采用蒸馏-沉淀聚合法合成球形网状结构的载药微球,在表面沉积金纳米粒子,并用氯金酸还原法,将沉积在微球上的氯金酸中Au^(3+)还原为Au°,并通过细胞实验检测该微球的毒性。结果:成功合成聚合物微球P(MAA-MBA)-EDA-FA-AuNP,发现其pH/温度的可控释药特性以及在高浓度下仍然保持较低毒性。结论:初步评价了P(MAA-MBA)-EDA-FA-AuNP聚合物微球作为抗肿瘤药物输送体系的潜力和优势。Objective： To prepare pH/temperature dual stimuli responsive polymer microspheres on controlled release of anti-tumor drugs at normal human body temperature and in acid environment for tumor cells. Methods： The drug carrier microspheres with spherical mesh structure were synthesized via distillation-precipitation polymerization. Gold nanoparticles were deposited on the surface of obtained microspheres, and then the Au3＋ was reduced to Au~ by chloroaurie acid reduction method. Finally, the toxicity of mierospheres was tested using cell experiments. Results： The polymer microspheres P （MAA-MBA）-EDA-FA-AuNP were successfully synthesized, which showed pH/temperature controlled drug release characteristic and low toxicity even at high concentration. Conclusion： The advantages of polymer microspheres P（MAA-MBA）-EDA-FA-AuNP may function as a potential anti-tumor drug delivery system.

关 键 词：蒸馏沉淀聚合 PH 温度 可控药物释放 

分 类 号：R94[医药卫生—药剂学]