ICP-MS法检测贵州10种地道药材中重金属元素含量  

Determination of Heavy Metals in 10 Kinds of Traditional Chinese Medicine from Guizhou Province by ICP-MS

作　　者：迟明艳[1] 李光芳 周雯[1] 

机构地区：[1]贵州医科大学药学院,贵州贵阳550025

出　　处：《贵阳医学院学报》2016年第7期783-786,共4页Journal of Guiyang Medical College

基　　金：贵州省科技计划项目[黔科合SY(2015)3035]

摘　　要：目的：检测10种贵州本地药材重金属的含量。方法：微波消解法处理10种药材样品，硝酸和过氧化氢作为消解体系，以锗（ Ge）、铟（ In）、铋（ Bi）作为内标元素，通过ICP-MS仪同时定量10种药材中的铅（ Pb）、镉（Cd）、汞（Hg）、砷（As）、铜（Cu）的含量。结果：各元素线性关系均良好（r﹥0.998），方法检出限为0.009-0.082μg/L，平均回收率为90.09%-99.16%，精密度和重复性的 RSD 值均小于5.0%；Cu 含量为1.502-6.803 mg /kg，As为0.172-1.816 mg/kg，Cd为0.000-0.230 mg/kg，Pb为0.163-3.909 mg/kg，Hg为0.000-0.087 mg/kg，5种中药材明确需要控制的有害重金属元素的残留量符合现行《药用植物及制剂进出口绿色行业标准》、《中国药典》（2015版）、GB-14882-94《食品中放射性物质限制浓度标准》限量指标。结论：ICP-MS具有简便、快速、准确、灵敏度高的优点，可用于中药材中重金属的定量测定。Objective：To detect the contents of heavy metals in ten kinds of traditional Chinese med-icines from Guizhou Province. Methods：Samples were conducted by microwave digestion instrument, with HNO3 and H2 O2 being the digestion acid system. Ge,In and Bi were used as internal standard el-ements,5 kinds of heavy metals（ Pb,Cd,Hg,As,Cu）were determined by ICP-MS in ten kinds of traditional Chinese medicines. Results：The linear relation of each element was good（r﹥0. 998）. The detection limit was 0. 009-0. 082 μg/L,the average recovery was 90. 09% -99. 16%,and the precision and repeatability of RSD values were less than 5%. Content of Cu was in the range of 1 . 502 to 6. 803 mg/kg,content of As was in the range of 0. 172 to 1. 816 mg/kg,content of Cd was in the range of 0. 000 to 0. 230 mg/kg,content of Pb was in the range of 0. 163 to 3. 909 mg/kg and content of Hg was in the range of 0. 000 to 0. 087 mg/kg. Residual quantity of five kinds of harmful heavy met-als（ Pb,Cd,Hg,As and Cu）needed to control met the limit standards of the《Current green trade standards of importing medicinal plants》,《Chinese pharmacopoeia》（ 2015 ）and GB-14882 -94 of the《Concentration of radioactive material limit standard in food》. Conclusion：This method was sim-ple,rapid,accurate,sensitive ,and suitable for the determination of heavy metals in traditional Chi-nese medicines and providedbasis for its quality control.

关 键 词：贵州 中药材 重金属 残留量 

分 类 号：R282.5[医药卫生—中药学]