Cytidine Mediated AuAg Nanoclusters as Bright Fluorescent Probe for Tumor Imaging in vivo  

作　　者：Leifeng Chen Yuanyuan Zhang Hui Jiang Xuemei Wang Chongyang Liu 

机构地区：[1]State Key Laboratory of Bioelectronics ( Chien-Shiung Wu Laboratory), Southeast University, Nanjing, Jiangsu 210096, China

出　　处：《Chinese Journal of Chemistry》2016年第6期589-593,共5页中国化学（英文版）

摘　　要：Noble metal clusters is an emerging class of fluorescent probes, avoiding most of the drawbacks of common fluorescent compounds, and they are simple to prepare and have good water solubility, good biocompatibility and excellent fluorescence properties. In this study, we have explored the synthesis of the cytidine mediated gold-silver nanoclusters （AuAg NCs） and applied it for both in vitro cellular imaging and tumor in vivo detection. Experimental results show that the as-prepared AuAg NCs can be used as a sensitive fluorescent probe for cancer cells/tissue de- tection. Especially, it is evident that under the relevant light irradiation with the wavelength of 488 nm, obviously bright fluorescence signal could be readily detected from focus location of inoculating tumor mouse, implying its possible application for the effective in vivo tumor bioimaging.Noble metal clusters is an emerging class of fluorescent probes, avoiding most of the drawbacks of common fluorescent compounds, and they are simple to prepare and have good water solubility, good biocompatibility and excellent fluorescence properties. In this study, we have explored the synthesis of the cytidine mediated gold-silver nanoclusters （AuAg NCs） and applied it for both in vitro cellular imaging and tumor in vivo detection. Experimental results show that the as-prepared AuAg NCs can be used as a sensitive fluorescent probe for cancer cells/tissue de- tection. Especially, it is evident that under the relevant light irradiation with the wavelength of 488 nm, obviously bright fluorescence signal could be readily detected from focus location of inoculating tumor mouse, implying its possible application for the effective in vivo tumor bioimaging.

关 键 词：fluorescence bioimaging cytidine mediated AuAg nanoclusters tumor bio-labeling 

分 类 号：Q523[生物学—生物化学] Q2-33