葡萄糖转运蛋白一1与肺动脉高压相关性研究进展  

Review of current researches on glucose transporter-1 in correlation with pulmonary hypertension

作　　者：孙青[1] 马正良[1] 李冰冰[1] 

机构地区：[1]南京大学医学院附属鼓楼医院麻醉科,210008

出　　处：《国际麻醉学与复苏杂志》2016年第7期658-662,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金青年科学基金（30901406,C160203）;江苏省自然科学基金面上项目（BK2012532）

摘　　要：背景肺动脉高压（pulmonary arterial hypertension, PAH）是一种常见的全身性疾病。研究发现PAH患者损伤部位的肺动脉平滑肌细胞伴有能量代谢异常，葡萄糖转运蛋（glucosetransporter，GLUT）-1异常高表达。目的探讨GLUT-1在PAH中的研究进展，为治疗PAH提供新的治疗策略。内容介绍GLUT-1的特性，探讨其在PAH疾病中上调的机制。趋向GLUT-1可能成为治疗PAH的新靶点，为PAH的治疗提供新方向。Backgroud Pulmonary arterial hypertension （PAH） is a common systemic disease. The study found the site of injury in patients with PAH associated with pulmonary vascular smooth muscle cell energy metabolism, glucose transporter （GLUT）-1 abnormally high expression. Objective The aim of this review is to discuss the role of GLUT-1 in PAH, provide new therapeutic strategies for the treatment of PAH. Content At first, the characteristics of GLUT-1 were introduced. Secondly, we explored the mechanism of disease increases in PAH. Trend GLUT-1 may be a new target for the treatment of PAH, providing new directions for the treatment of PAH.

关 键 词：肺动脉高压 葡萄糖转运蛋白-1 

分 类 号：R544.1[医药卫生—心血管疾病]