盐酸氨基葡萄糖治疗膝骨关节炎的疗效及安全性分析  

Clinical Efficacy and Safety of Glucosamine Hydrochloride in the Treatment of Osteoarthritis

作　　者：岑毅[1] 严光建[2] 王传恩[2] 

机构地区：[1]成都体育学院附属体育医院急诊科,成都610041 [2]成都体育学院附属体育医院脊柱科,成都610041

出　　处：《华西医学》2016年第7期1164-1166,共3页West China Medical Journal

摘　　要：目的探讨临床应用盐酸氨基葡萄糖治疗膝骨关节炎的疗效及安全性。方法选取2014年4月-2015年4月收治的150例膝骨关节炎患者,按随机数字表法分为试验组和对照组,每组各75例。试验组口服盐酸氨基葡萄糖,对照组口服双氯芬酸钠,分别于治疗前,治疗2、4、6、8周和停药2周后计算Lequesne指数、总有效率和不良反应发生率。结果两组Lequesne指数在治疗2周后明显下降(P<0.05),治疗8周后达到最低,停药2周后两组的Lequesne指数仍然显著低于治疗前(P<0.05)。对照组和试验组治疗8周后的总有效率分别为83.1%和80.9%,停药2周后总有效率分别为80.0%和79.4%,差异无统计学意义(P>0.05)。对照组和试验组的不良反应发生率分别为21.3%和6.7%,差异有统计学意义(P<0.05)。结论盐酸氨基葡萄糖治疗膝骨关节炎具有良好的疗效和较高的安全性,适合长期服用。Objective To evaluate the efficacy and safety of glucosamine hydrochloride in the treatment of osteoarthritis.Methods A total of 150 patients with osteoarthritis treated between April 2014 and April 2015 were randomly divided into control group and trial group with 75 in each.Patients in the trial group accepted oral glucosamine hydrochloride,while those in the control group were given diclofenac sodium.Lequesne index,total effective rate and the incidence of adverse reactions of both groups were calculated before and 2,4,6 and 8 weeks after treatment,and 2 weeks after drug withdrawal.Results In both groups,Lequesne index started to decrease after 2 weeks of treatment（P〈 0.05）,and reached the minimum value at treatment week eight（P〈 0.05）.The Lequesne index 2 weeks after drug withdrawal was still obviously lower than that before treatment（P〈 0.05）.There was no significant differences in the total effective rate at treatment week eight（83.1%for the control group and 80.9%for the trial group） or the total effective rate 2 weeks after drug withdrawal（80.0%for the control group and 79.4%for the trial group） between the control group and the trial group（P〉 0.05）.The incidence of adverse reactions of the trial group（6.7%） was significantly lower than that of the control group（21.3%）（P〈 0.05）.Conclusion Glucosamine hydrochloride is effective and safe in the treatment of osteoarthritis,which is suitable for long-term treatment.

关 键 词：骨关节炎 膝 盐酸氨基葡萄糖 疗效 安全性 

分 类 号：R684.3[医药卫生—骨科学]