盐酸氨基葡萄糖治疗腰椎小关节骨关节炎的疗效分析  

Efficacy of Glucosamine Hydrochloride in the Treatment of Lumbar Facet Joint Osteoarthritis

作　　者：舒剑臣[1] 史可测 朱宇[1] 刘波[1] 

机构地区：[1]乐山市人民医院骨科,四川乐山614200

出　　处：《华西医学》2016年第7期1170-1173,共4页West China Medical Journal

摘　　要：目的探讨盐酸氨基葡萄糖在腰椎小关节骨关节炎治疗中的临床疗效,为临床治疗腰椎小关节骨关节炎寻找最佳治疗方案提供临床线索。方法选择2014年8月-2015年8月收治的120例腰椎小关节骨关节炎伴下腰痛患者,随机分为3组,每组40例。甲组采用口服盐酸氨基葡萄糖治疗,乙组采取口服洛索洛芬钠治疗,丙组采取口服盐酸氨基葡萄糖+洛索洛芬钠治疗,疗程均为8周。随访16周,比较治疗前、治疗8周后以及停药8周后患者的Oswestry功能障碍指数(ODI)和视觉模拟疼痛评分(VAS)结果。结果 120例患者中,3例乙组患者服药后出现上消化道中度疼痛,放弃治疗;12例乙组患者出现上消化道轻度不适,经对症处理后好转;甲组和丙组未见药物相关不良反应。共117例完成8周治疗,并全部获得随访。甲、乙、丙组治疗前VAS和ODI评分比较差异无统计学意义(P>0.05);治疗后各组VAS和ODI评分与治疗前比较差异均有统计学意义(P<0.05);治疗8周后乙、丙组的疗效优于甲组,差异有统计学意义(P<0.05),但乙、丙组比较差异无统计学意义(P>0.05);停药8周后,甲、丙组的疗效优于乙组,差异有统计学意义(P<0.05),但甲、丙组比较差异无统计学意义(P>0.05)。结论盐酸氨基葡萄糖对腰椎小关节骨关节炎所引起的下腰痛疗效确切,并且避免了非甾体类抗炎药相关并发症风险,值得临床推广应用。Objective To analyze the clinical efficacy of glucosamine hydrochloride in the treatment of lumbar facet joint osteoarthritis,in order to provide the most appropriate treatment for lumbar facet joint osteoarthritis.Methods A total of 120 patients with lumbar facet joint osteoarthritis and low back pain treated between August 2014 and August 2015 were randomly divided into three groups with 40 in each.Group A was treated with glucosamine hydrochloride;group B accepted loxoprofen-sodium;and group C was given glucosamine hydrochloride plus loxoprofensodium.The courses of treatment were all 8 weeks in the three groups.Follow-up lasted for 16 weeks.Oswestry disability index（ODI） and visual analogue score（VAS） of the patients were compared before treatment,8 weeks after treatment,and8 weeks after withdrawal.Results Three patients in group B gave up treatment due to upper gastrointestinal moderate pain after taking the drug.Another 12 patients in group B suffered from upper gastrointestinal mild discomfort,and the symptoms alleviated after accepting symptomatic treatment.There were no drug-related adverse reactions in group A and C.A total of 117 patients completed the 8-week treatment and were all followed up.Before treatment,the ODI scores and VAS scores were not significantly different among the groups（P〉 0.05）.After treatment,the scores changed significantly in all the groups（P〈 0.05）.At week 8 after treatment,the clinical efficacy in group B and C was superior to that in group A,and the differences were statistically significant（P〈 0.05）,but there was no significant difference between group B and C（P〈 0.05）.Eight weeks after withdrawal,the clinical efficacy in group A and C was better than that in group B,and the differences were statistically significant（P〉 0.05）,but there was no significant difference between group A and C（P〈 0.05）.Conclusions Glucosamine hydrochloride is effective for low back pain caused by lumbar facet joint osteoarthritis,which has no non-steroidal

关 键 词：盐酸氨基葡萄糖 腰椎 小关节 骨关节炎 下腰痛 

分 类 号：R684.3[医药卫生—骨科学]