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作 者:赵娅[1] 唐进法[1] 张辉[1] 李伟霞[1] 曹英杰[1] 孟祥乐[1] 李学林[1]
机构地区:[1]河南中医药大学第一附属医院,郑州450000
出 处:《中国新药杂志》2016年第14期1647-1651,共5页Chinese Journal of New Drugs
基 金:国家自然科学基金-河南省人民政府人才培养联合基金资助项目(U1304824);中国博士后科学基金特别资助项目(2015T80772);中国博士后科学基金面上资助项目(2015M582190);河南省科技攻关项目(102102310077);河南省博士后基金资助项目(2014-75)
摘 要:目的:研究丹红注射液与维生素B_6注射液在5%葡萄糖注射液(5%GS)、0.9%氯化钠注射液(0.9%NS)中的配伍稳定性。方法:采用超高效液相色谱法测定丹红注射液与维生素B_6注射液配伍后放置0,1,4 h内丹参素钠、原儿茶醛、咖啡酸、对香豆酸、迷迭香酸和丹酚酸B及维生素B_6的含量变化;采用不溶性微粒检测仪、酸度计测定配伍后放置0,0.5,1,2,4 h不溶性微粒数及p H值,并观察外观变化。结果:丹红注射液与维生素B_6注射液配伍在5%GS、0.9%NS中均为黄褐色,澄清透明液体,4 h内无明显变化;不溶性微粒数及p H值均在药典规定的范围之内;在4 h内,以5%GS为溶媒时,丹红注射液的6种有效成分及维生素B_6的含量无明显变化;以0.9%NS为溶媒时,丹红注射液中6种有效成分的含量保持在94%~106%范围内,维生素B_6在1 h时检测不到。结论:丹红注射液与维生素B_6注射液可在5%GS中配伍使用,不能以0.9%NS为溶媒进行配伍。Objective: To investigate the compatible stability of Danhong injection mixed with vitamin B_6 injection in two kinds of solutions( 5% glucose injection and 0. 9% sodium chloride injection). Methods: UPLC was used to detect the content change( salvianic acid A sodium,protocatechuic aldehyde,caffeic acid,p-coumaric acid,rosmarinic acid,salvianolic acid B,and isosorbide mononitrate) of the mixture within 4 h after mixing. The amount of insoluble particles,p H value,and appearance were also observed. Results: Neither the appearance and p H value and the amount of insoluble particles had obvious changes. No significant difference was found in the contents of salvianic acid A sodium,protocatechuic aldehyde,caffeic acid,p-coumaric acid,rosmarinic acid and salvianolic acid B in two kinds of solutions after Danhong injection mixed with vitamin B_6 injection. Vitamin B_6 was also stable in 5% glucose injection within 4 h,but was not detected in 0. 9% sodium chloride injection after mixing. Conclusion: Danhong injection can be mixed with vitamin B_6 injection in 5% glucose injection within 4 h after mixing,but not in 0. 9% sodium chloride injection.
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