煤工尘肺进行性大块纤维化与肺功能关系的研究  

Study on relationship between progressive massive fibrosis and pulmonary function in patients with coal worker's pneumoconiosis

作　　者：曹香府[1] 赵倩[1] 崔玉芳[1] 李俊英[1] 

机构地区：[1]国家安全生产监督管理总局职业安全卫生研究中心石龙医院门诊部,北京102308

出　　处：《职业与健康》2016年第11期1473-1475,1479,共4页Occupation and Health

摘　　要：目的探讨煤工尘肺进行性大块纤维化(progressive massive fabrosis,PMF)对呼吸功能的影响。方法于2014年1月—2015年5月从北京京煤集团有限责任公司煤工尘肺病患者中选取有PMF的患者41例为观察组(PMF组),另选同公司煤工尘肺病患者中无PMF的患者84例为对照组。观察呼吸频率和呼吸困难分级情况;肺功能各项指标、PaO_2(氧分压)、PaCO_2(二氧化碳分压)。应用SPSS 13.0统计软件包分析并处理数据。结果 PMF组与对照组呼吸频率比较,差异无统计学意义(P>0.05);呼吸困难分级比较,差异有统计学意义(P<0.05)。PMF组PaO_2明显低于对照组,而PaCO_2两组间差异无统计学意义。两组肺功能障碍类型均以混合性多见,其次是限制性。PMF组肺功能中重度损伤明显高于对照组,其差异有统计学意义(P<0.05)。PMF组FEV_(1.0)/FVC%、PEF、FEF 25%-75%、MEF 75%、MEF 50%、MEF 25%两组指标比较,差异有统计学意义(P<0.05)。结论 PMF可加重尘肺病患者的呼吸困难和肺功能损伤。[Objective]To explore the influence of progressive massive fibrosis（PMF） on pulmonary function in patients with coal worker＇s pneumoconiosis. [Methods]41 coal worker＇s pneumoconiosis patients with PMF collected from Beijing Jingmei Group Company from January 2014 to May 2015 were enrolled in the PMF group,while 84 coal worker＇s pneumoconiosis patients without PMF collected from same company were recruited in the control group. The respiratory rate,dyspnea classification,pulmonary function indexes,PaO_2 and PaCO_2 were observed. SPSS 13.0 software was used to analyze the data.[Results] The difference in the respiratory rate was not statistically significant between the PMF group and the control group（P〈0.05）,while the difference in dyspnea classification was statistically significant（P〈0.05）. PaO_2 level in the PMF group was significantly lower than that in the control group,and there was no statistically significant difference in Pa CO2 level between two groups. The main type of lung dysfunction in two groups was mixed type,followed by the restricted type. The proportion of severe impairment of lung function in the PMF group was higher than that in the control group,and the difference was statistically significant（P 0.05）. There were statistically significant differences in the levels of FEV1.0/FVC%,PEF,FEF 25%-75%,MEF 75%,MEF 50% and MEF 25% between two groups（P〈0.05）.[Conclusion]PMF may aggravate the dyspnea and Pulmonary Injury in patients with pneumoconiosis.

关 键 词：煤工尘肺 进行性大块纤维化 呼吸功能 

分 类 号：R135.2[医药卫生—劳动卫生]