一测多评法测定大黄胶囊中大黄素和大黄酚  

Determination of Emodin and Chrysophanol in Dahuang Capsules by Quantitative Analysis of Multi-Components by Single-Marker

作　　者：邬伟魁 严倩茹 宋增炫 

机构地区：[1]梅州市食品药品监督检验所,广东梅州514071

出　　处：《解放军药学学报》2016年第3期236-238,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的建立大黄胶囊中大黄素和大黄酚的一测多评测定法。方法建立HPLC法测定大黄素与大黄酚间的相对校正因子,并应用于大黄胶囊,比较计算值与测得值的差异。结果用一测多评法对4批样品中大黄素和大黄酚进行测定,与外标法实测值基本一致。结论该方法可靠,结果准确,可用于大黄胶囊质量控制。Objective To develop a method for quantitative analysis of multi-components by single marker （QAMS） in order to determine the content of emodin and chrysophanol in Dahuang capsules. Methods An HPLC method was developed as QAMS. Using emodin as the internal reference substance, the relative correction factor of chrysophanol was determined by HPLC with good reproducibility. The content of the components in 4 batches of samples was determined by both QAMS and external standard method. Results No significant difference was observed between the quantitative results of QAMS method and those of the external standard method. Conclusion This mothod can be used to control the quality of Dahuartg capsules.

关 键 词：一测多评 大黄胶囊 大黄素 大黄酚 

分 类 号：R927.2[医药卫生—药学]