舍他康唑对常见临床分离念珠菌属菌株的体外抗菌活性研究  

In vitro antifungal activity of sertaconazole against clinical isolates of Candida spp.

作　　者：王千[1] 吴伟伟[1] 张浩[1] 万喆[1] 李若瑜[1] 王爱平[1] 刘伟[1] 

机构地区：[1]北京大学第一医院皮肤性病科北京大学真菌和真菌病研究中心皮肤病分子诊断北京市重点实验室,北京100034

出　　处：《中国真菌学杂志》2016年第3期153-155,共3页Chinese Journal of Mycology

基　　金：中国中西医结合学会--皮肤病研究基金;国家自然科学基金(81471925)

摘　　要：目的 了解舍他康唑对常见临床分离念珠菌属菌株的体外抗菌活性。方法 参照美国临床和实验室标准协会（Clinical and Laboratory Standards Institute,CLSI）制定的M27-A3方案测定舍他康唑对112株念珠菌的MIC值。结果 舍他康唑对112株念珠菌在24h的MIC GM为0.18μg/mL,MIC范围为≤0.03-16μg/mL,MIC50和MIC90分别为0.125μg/mL、1μg/mL。对念珠菌属各菌种的MIC GM从低到高依次为白念珠菌0.08μg/mL,光滑念珠菌0.158μg/mL,近平滑念珠菌0.318μg/mL,热带念珠菌为0.425μg/mL,克柔念珠菌为1.414μg/mL。结论 舍他康唑对常见临床分离念珠菌属菌株均有较好的体外抗菌活性。Objective To investigate the in vitro antifungal activity of sertaconazole against the clinical strains of Candida spp.isolated from China.Methods Minimal inhibitory concentration （MIC） of sertaconazole against 112 strains were tested by using CLSI （Clinical and Laboratory Standards Institute）broth microdilution method M27-A3.Results The overall geometric mean 24 h MIC of sertaconazole was 0.18 /μg/mL with a MIC range of≤0.03-16/μg/mL,MICs0 and MIC90 of sertac- onazole were 0.125 /μg/mL, 1 pg/mL,respectively.In the same time,the geometric mean MIC was 0.080 /μg/mL for C.albi- cans ,0.158μg/mL for C.glabrata ,0.318 μg/mL for C.parapsilosis ,0.425 μg/mL for C.tropicalis, 1.414 μg/mL for Ckrusei.Conclusion Sertaconazole is active against pathogenic Candida spp..

关 键 词：舍他康唑 念珠菌属 体外 敏感性试验 

分 类 号：R978.5[医药卫生—药品]