本院铜绿假单胞菌的耐药率与抗菌药物用量的相关性分析  

Analysis of relationship between the resistance rate of Pseudomonas aeruginosa and the doses of antibacterials in our hospital

作　　者：何清华[1] 邓白荔 黎汉坤[1] 曹堃[1] 杨婉霞[1] 郭卫[1] 黄云平[1] 

机构地区：[1]湛江中心人民医院,广东湛江524037

出　　处：《药学研究》2016年第8期484-487,共4页Journal of Pharmaceutical Research

摘　　要：目的分析近5年本院铜绿假单胞菌对常用抗菌药物耐药率与药物使用频度的相关性,为临床合理使用抗菌药物提供参考依据。方法采用收集、统计、相关性分析方法,对本院2010~2014年住院患者各类标本培养分离出的铜绿假单胞菌耐药情况和11种具有抗铜绿假单胞菌活性的抗菌药物使用频度进行回顾性分析。结果5年分离出非重复铜绿假单胞菌1 510株。铜绿假单胞菌对哌拉西林/他唑巴坦、亚胺培南的耐药率与头孢噻肟的使用频度呈正相关（r=0.917,P〈0.05;r=0.880,P〈0.05）;哌拉西林的耐药率与哌拉西林、头孢噻肟的用量呈正相关（r=0.902,P〈0.05;r=0.944,P〈0.05）;对头孢他啶的耐药率与头孢噻肟、阿米卡星用量呈正相关（r=0.904,P〈0.05;r=0.907,P〈0.05）。结论本院临床检出的铜绿假单胞菌对常用抗菌药物耐药性与抗菌药物使用频度之间存在相关关系,临床中应严谨规范使用抗菌药物,优化初始抗感染治疗方案,降低抗菌药物选用压力和临床用量,以有效控制细菌耐药菌株的产生。Objective To analyse the relationship between the resistance rate of Pseudomonas aeruginosa and the use frequency of antibacterials within recent 5 years and provide references for the reasonable use of antibacterials.Methods Collecting,statistics,associativity analytical methods were adopted.The resistance information of Pseudomonas aeruginosa obtained from 2010 ~ 2014 in our hospital and the use frequency of 11 antibacterials with resistance activity for Pseudomonas aeruginosa were retrospectively analysed.Results During the 5 years,1 510 strains of Pseudomonas aeruginosa were separated.The resistance rates of Piperacillin / Tazobactam and Imipenem had positive relationship with the use frequency of Cefotaxime（ r = 0.917,P〈0.05; r = 0.880,P〈0.05）; The resistance rate of Piperacillin also had positive relationship with the use frequency of Piperacillin and Cefotaxime（ r = 0. 902,P 〈 0. 05; r = 0. 944,P 〈 0. 05）; The resistance rate of Ceftazidime also had positive relationship with the use frequency of Cefotaxime and Amikacin（ r = 0.904,P〈0.05; r = 0.907,P〈0.05）.Conclusion The resistance rate of Pseudomonas aeruginosa obtained in our hospital had relationship with the use frequency of antibacterials.The use of antibacterials should be rigorous and standard,initial anti-infective therapeutic schedule should be optimized to reduce the need of antibacterials and their doses,by this way,we could control the drug resistant strains of bacteria.

关 键 词：铜绿假单胞菌 细菌耐药性 药物使用频度 抗菌药物 

分 类 号：R978.5[医药卫生—药品]