吡拉西坦有关物质的合成  

Synthesis of related substances of piracetam

作　　者：徐玉文 郑静 王小兵 

机构地区：[1]山东省食品药品检验研究院,山东济南250101

出　　处：《药学研究》2016年第8期494-496,共3页Journal of Pharmaceutical Research

基　　金：2015年国家药品计划抽验项目资助(No.2015-49)

摘　　要：目的研究吡拉西坦1个有关物质的合成方法。方法以4-氨基丁酸为起始原料,经过酯化、磺酰化等6步反应制得中间体4-[N-(9-芴甲氧基羰基)-N-(氨甲酰甲基)]氨基丁酸,最后经哌啶水解生成4-(N-氨甲酰甲基)氨基丁酸。结果最终产物经核磁共振氢谱(1H-NMR)和质谱(MS)确证结构。结论本研究合成了1个吡拉西坦的有关物质,作为吡拉西坦的质量研究的重要参照物。Objective To study the chemical synthesis of one related substance of piracetam.Methods One intermediate was synthesized from 4-amino butyric acid by esterification reaction,sulfonated reaction and other 4 steps reaction.4-（ N-formamyl methyl） amino butyric acid was obtained by hydrolysis process of the intermediate in piperidine.Results The structure of end product was confirmed by MS,1H-NMR.Conclusion One related substance of piracetam was synthesized successfully in this study.This substance was taken as the reference for the quality control of piracetam.

关 键 词：吡拉西坦 有关物质 合成 益智药 

分 类 号：R914.5[医药卫生—药物化学]