血浆脂肪细胞型脂肪酸结合蛋白与2型糖尿病患者慢性肾脏病的相关性研究  

Correlation Research Between Adipocyte Fatty Acid-Binding Proteinand Chronic Kidney Disease In Patients with Type 2 Diabetes

作　　者：章娜[1] 刘琳[1] 严宗逊[1] 

机构地区：[1]川北医学院附属医院内分泌科,四川南充637000

出　　处：《四川医学》2016年第7期760-763,共4页Sichuan Medical Journal

摘　　要：目的探索血浆脂肪细胞型脂肪酸结合蛋白(A-FABP)与2型糖尿病(T2DM)患者慢性肾脏病(CKD)的相关性。方法回顾性分析178名T2DM患者的临床资料,采用酶联免疫吸附法测定患者血浆A-FABP水平,慢性肾脏病定义为肾小球滤过率估计值(e GFR)<60 m L/(min·1.73m^2)。结果血浆A-FABP水平与e GFR成负相关(r=-0.43,P<0.05),调整其它相关因素后,其与e GFR值之间仍存在相关关系。血浆A-FABP中位数为20.3ng/m L,高于或低于该值,CKD发生率差异有统计学意义(P<0.05)。多因素logistic回归分析显示血浆A-FABP水平是糖尿病患者发生CKD的独立危险因素[OR=4.561,95%CI(1.352,9.223),P<0.05]。结论血浆A-FABP水平是T2DM患者CKD发生的独立危险因素之一,对于预测T2DM发生CKD有一定的意义。Objective To explore the relationship between adipocyte fatty acid-binding protein（ A-FABP） and chronic kidney disease（ CKD） in patients with type 2 Diabetes（ T2DM）. Methods The clinical data of 178 patients with T2 DM were analyzed retrospectively,and the plasma A-FABP level was determined by enzyme linked immunosorbent assay. Chronic kidney disease is defined that the estimated glomerular filtration rate（ e GFR） 60 m L /（ min ·1. 73m^2）. Results There was negative correlation between plasma A-FABP level and e GFR（ r =-0. 43,P〈0. 05）,and this relationship still existed after other relevant factors were adjusted. The median of plasma A-FABP was 20. 3 ng / m L,and the difference of CKD incidence was statistically significant between patients with plasma A-FABP level above the median and below the median（ P〈0. 05）. The multiple logistic regression analysis showed that plasma A- FABP level was an independent risk factor for CKD in patients with diabetes[OR = 4. 561,95% CI（ 1. 352,9. 223）,P〈0. 05]. Conclusion Plasma A-FABP level was one of the independent risk factors for CKD in patients with T2 DM,which was beneficial for predicting the occurrence of CKD in T2 DM patients.

关 键 词：2型 糖尿病 慢性肾脏病 脂肪型脂肪酸结合蛋白 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]