基于PCA-GRA的补阳还五汤及其精简方抗脑缺血损伤功效的谱效关系研究  

The Spectrum-Effect Relationship of Buyang Huanwu and its Optimized Prescriptions on Cebebral Ischemia Injury Based on PCA-GRA Method

作　　者：刘青萍[1] 晏峻峰[1] 杨欣[2] 夏相宜 张水寒[2] 刘芳[3] 王宇红[3] 蔡光先[3] 

机构地区：[1]湖南中医药大学管理与信息工程学院,湖南长沙410208 [2]湖南省中医药研究院,湖南长沙410006 [3]湖南中医药大学湖南省中药粉体与创新药物省部共建国家重点实验室培育基地中药粉体关键技术及装备国家地方联合工程实验室,湖南长沙410208

出　　处：《湖南中医药大学学报》2016年第9期13-15,56,共4页Journal of Hunan University of Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)课题(2012CB723503);湖南省教育厅科技项目(13C683;13C672);湖南省教育厅(KC2011B027);湖南省中药粉体与创新药物省部共建国家重点实验室培育基地开放基金(2013年);中医药数字化技术基础研究平台

摘　　要：采用高效液相色谱法获取12批补阳还五汤全方、14批补阳还五汤精简方指纹图谱化学成分的数据,运用主成分分析法(principal component analysis,PCA)对采集的数据进行降维处理,计算出综合排名第一的中药材指纹图谱批次。运用灰色关联度法(grey relational analysis,GRA)将所求批次的指纹图谱特征峰和脑损伤的保护作用关联起来,探讨补阳还五汤全方及精简方中指纹图谱共有峰和特有峰与脑损伤保护作用贡献程度的强弱关系。本研究结合PCA和GRA开展补阳还五汤谱效关系研究,能提升数据的有效性和准确度。The HPLC fingerprint of the 12 batches of Buyang Huanwu Decoction and the 14 batches of its optimized prescriptions were determined. The principal component analysis（PCA） was used to reduce the data dimension. The ranked first batch of fingerprints of Chinese medicines were evaluated. The protective effects of brain damage and the characteristic peaks were correlated by grey relational analysis（GRA）. The correlation between common peaks and charactersistic peaks of Buyang Huanwu Decoction and its optimized prescriptions with its contribution onthe protective effect of cebebral ischemia were discussed. According to the method of PCA and GRA, the spectrum-effect relationship research of Buyang Huanwu Decoction can be improved effectively and accurately.

关 键 词：补阳还五汤 谱效关系 主成分分析 灰色关联度 脑缺血损伤 

分 类 号：R285[医药卫生—中药学]