化瘀抗癌汤预防肺癌化疗患者静脉血栓形成临床研究  

Huayu Anti-cancer Decoction Preventing Venous Thrombosis with Lung Cancer Patients after Chemotherapy

作　　者：张翼[1] 王红玲[1] 韩亮[2] 蒋士卿[3] 

机构地区：[1]河南中医药大学第三附属医院,河南郑州450008 [2]河南省中医院,河南郑州450000 [3]河南中医药大学,河南郑州450046

出　　处：《中医学报》2016年第7期940-942,共3页Acta Chinese Medicine

基　　金：河南省重点科技攻关项目(082102310028)

摘　　要：目的:探讨化瘀抗癌汤预防肺癌化疗患者静脉血栓形成的临床疗效及安全性。方法:将214例肺癌化疗患者按数字表法随机分为对照组和观察组每组107例,对照组给予预防性抗凝,观察组于化疗开始时口服化瘀抗癌汤,持续至化疗结束14 d。观察两组肺栓塞、深静脉血栓形成等静脉血栓栓塞症事件及D-二聚体、血小板计数、血浆纤维蛋白原、血小板聚集率等凝血标志物评价疗效,对比出血事件评价安全性。结果:观察组深静脉血栓形成发生率1.87%、肺栓塞发生率0.93%、静脉血栓栓塞症发生率2.80%均分别低于对照组的11.21%、6.54%、17.76%,差异均有统计学意义(P<0.05);对照组治疗后血浆纤维蛋白原、D-二聚体、血小板计数、血小板聚集率均较治疗前明显升高,观察组治疗后血浆纤维蛋白原、D-二聚体、血小板计数、血小板聚集率均较治疗前明显降低,且明显低于对照组,差异均有统计学意义(P<0.05);观察组高危害出血、低危害出血及血小板减少等发生率均略高于对照组,差异无统计学意义(P>0.05)。结论:化瘀抗癌汤可显著改善肺癌化疗患者高凝状态,降低静脉血栓栓塞症发生风险,安全性高。Objective： To investigate the efficacy and safety of Huayu Anti-cancer Decoction in prevention of venous thrombosis with lung cancer patients after chemotherapy. Methods： 214 cases of lung cancer patients were randomly divided into control group and observation group,with 107 cases in each group. The method of prophylactic anticoagulation was applied to the control group. As to the observation group,Huayu anti-cancer Decoction was given during the whole process of chemotherapy for 14 d. The venous thromboembolism events including pulmonary embolism and deep vein thrombosis,as well as the coagulation markers such as Ddimer,platelet count,Plasma fibrinogen,platelet aggregation rate and bleeding events of both groups were compared to evaluate the efficacy and safety of the treatment. Results： The incidence rate of deep vein thrombosis（ 1. 87%）,the incidence rate of pulmonary embolism（ 0. 93%） and the incidence rate of venous thromboembolism（ 2. 80%） of the treatment group was significantly lower respectively than those of the control group（ 11. 21%,6. 54%,17. 76% respectively）（ P 〈0. 05）. The plasma fibrinogen,D-dimer,platelet count and platelet aggregation rate of the control group was significantly higher than those before treatment,while the plasma fibrinogen,D-dimer,platelet count,and platelet aggregation rate of the observation group was significantly decreased after treatment. The differences of those indexes of both groups were statistically significant（ P 〈0. 05）. The incidence rates of high hazard bleeding,low hazard bleeding and thrombocytopenia of the observation group were slightly higher than those of the control group,and the differences were not statistically significant（ P 〈0. 05）. Conclusion： Huayu anti-cancer decoction can safely and significantly improve lung cancer patients＇ hypercoagulable state after chemotherapy,by reducing the risk of venous thromboembolism.

关 键 词：肺癌 化瘀抗癌汤 化疗 静脉血栓形成 

分 类 号：R273.42[医药卫生—中西医结合]