促红细胞生成素对经皮冠状动脉介入治疗术后再灌注性心律失常的作用分析  

The effect of erythropoietin on reperfusion arrhythmia in patients after PCI

作　　者：李彦明[1] 何瑞利[1] 赵翠花[1] 张韩[1] 洪岩[1] 万琪琳[1] 程冠昌[1] 

机构地区：[1]河南大学淮河医院心内科,河南开封475000

出　　处：《临床心血管病杂志》2016年第7期690-693,共4页Journal of Clinical Cardiology

基　　金：河南省2014年国际科技合作计划项目(No:144300510074);河南省基础与前沿技术研究计划项目(No:152300410065)

摘　　要：目的:观察促红细胞生成素(EPO)对急性心肌梗死患者经皮冠状动脉介入治疗(PCI)术后再灌注性心律失常的影响。方法:选取急性ST段抬高型心肌梗死且成功行PCI的患者120例,将其随机分为EPO 100 U/kg组、EPO 1 000 U/kg组及对照组,每组40例。EPO 100 U/kg组和EPO 1 000 U/kg组在PCI术前分别给予100 U/kg和1 000U/kg的EPO,对照组给予0.9%氯化钠溶液,观察PCI术后再灌注性心律失常发生情况,记录随访期间的主要不良心脏事件(MACE)及EPO相关不良反应发生情况。结果:共74例出现再灌注性心律失常(63.33%)。EPO 1 000 U/kg组房性期前收缩、心房颤动、室性期前收缩、室性心动过速、总心律失常发生率及室性心律失常评分均低于对照组(均P<0.05);EPO 100U/kg组房性期前收缩、心房颤动、室性期前收缩发生率低于对照组(均P<0.05)。3组患者随访6个月后不良反应发生无统计学差异。结论:急性心肌梗死患者PCI术前给予EPO对再灌注性心律失常具有一定缓解作用。Objective：To explore the effect of erythropoietin（EPO）on reperfusion arrhythmia in patients with acute myocardial infarction after PCI.Method：A total of 120 AMI patients after PCI was randomized into EPO100U/kg group,EPO 1 000U/kg group and control group.Patients in EPO 100U/kg group and EPO 1 000U/kg group were given 100U/kg or 1 000U/kg EPO before PCI,while saline was given in control group.The occurrence of reperfusion arrhythmia was detected.EPO related side effects and major adverse cardiovascualer events（MACE）were also compared.Result：The occurrence of reperfusion arrhythmia was 63.33%（76/120）among all patients.The incidence of atrial premature beats,auricular fibrillation,premature ventricular contraction,ventricular tachycardia,overall arrhythmia and ventricular arrhythmia score were significantly lower in EPO 1000U/kg group（all P〈0.05）;the incidence of atrial premature beats,auricular fibrillation and premature ventricular contraction were lower in EPO100U/kg group than in control group（all P〈0.05）.The incidence of EPO related side effects and MACE among the three groupswere not significant different.Conclusion：The administration of EPO before PCI might has positive effects on the control of reperfusion arrhythmia.

关 键 词：促红细胞生成素 经皮冠状动脉介入治疗 急性心肌梗死 再灌注性心律失常 室性心律失常 

分 类 号：R541.7[医药卫生—心血管疾病]