老年原发性高血压病患者动态血压节律与肾功能损害的相关性研究  

The correlation between ambulatory blood pressure rhythm and renal function impairment in elderly patients with essential hypertension

作　　者：徐慧敏[1] 

机构地区：[1]河南大学淮河医院,河南开封475000

出　　处：《临床心血管病杂志》2016年第7期698-701,共4页Journal of Clinical Cardiology

摘　　要：目的:探讨老年原发性高血压病患者动态血压节律与肾功能损害的相关性。方法:选择老年原发性高血压患者262例,根据动态血压监测结果分为健康对照组、杓性组、非杓性组。检测各组微量白蛋白(MAU)、尿肌酐(Cr)及二者比值(UACR),用简单线性相关分析其与动态血压各参数之间的相关性。结果:杓性组和非杓性组MAU和UACR明显高于对照组,而非杓性组高于杓性组(均P<0.05)。MAU与UACR均与24h平均收缩压、24h平均舒张压、夜间平均收缩压、夜间平均收缩压呈正相关。结论:MAU和UACR是老年高血压患者肾功能损害预测指标,MAU和UACR与24h动态血压呈明显相关性,其中UACR与24h动态血压的相关性较显著。Objective：To study the relationship between ambulatory blood pressure rhythm and renal function impairment in elderly patients with essential hypertension.Method：A total of 262 elderly patients with essential hypertension was enrolled and divided into health control group,dipper rhythm group and non dipper rhythm group according to the results of the dynamic blood pressure monitoring.Microalbuminuria（MAU）,urine creatinine（Cr）and both ratio（UACR）were detected.Simple linear correlation analysis was used to test the correlation among MAU,Cr,UACR and the parameters of dynamic blood pressure.Result：The levels of MAU and UACR was obviously higher in dipper rhythm group and non dipper rhythm group than those in control group,and was higher in non dipper rhythm group than those in dipper rhythm group（all P〈0.05）.MAU and UACR had a positive correlation with 24h-DBP,24h-SBP,n-SBP and n-DBP.Conclusion：MAU and UACR are predictors in elderly patients with hypertension renal impairment.There is a significantly association among MAU,UACR and 24-hour ambulatory blood pressure.

关 键 词：高血压 原发性 尿微量白蛋白 尿肌酐 

分 类 号：R544.1[医药卫生—心血管疾病]