完全性脊髓损伤后血清S-100β蛋白浓度的变化  

Changes of Serum S-100β Protein after Complete Spinal Cord Injury

作　　者：王玉明[1,2] 朱致敏 车俊艳 李慧兰[1,2] 马科[1,2] 宫慧明[1,2] 陈惠[1,2] 钟华[3] 杨明亮[1,2] 杜良杰[1,2] 

机构地区：[1]中国康复研究中心北京博爱医院,北京市100068 [2]首都医科大学康复医学院,北京市100068 [3]广东省廉江市人民医院,广东廉江市524400

出　　处：《中国康复理论与实践》2016年第7期824-826,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中央级公益性科研院所基本科研业务费专项资金项目(No.2012CZ-35)

摘　　要：目的评价S-100β蛋白能否成为创伤性脊髓损伤的血清标记物。方法 2013年6月~2014年10月,选取完全性脊髓损伤患者24例,分别在损伤后1周、3个月、6个月抽血,采用酶联免疫吸附法测定血清中S-100β蛋白浓度,以10名健康人血清作为正常对照。结果 S-100β蛋白血清浓度在损伤后1周、3个月时显著升高（Z〉4.273,P〈0.001）。结论 S-100β蛋白血清浓度升高可能有助于评估完全性脊髓损伤后早期的组织损伤。Objective To evaluate whether S- 100β protein could be a serum marker for traumatic spinal cord injury（SCI）. Methods From June, 2013 to October, 2014, 24 patients with complete SCI were measured the serum S- 100β protein concentrations with enzyme-linked immunosorbent assay, one week, three and six months after SCI. Serum from ten healthy persons was as normal control. Results The serum S-100β protein concentrations increased one week and 3 months after SCI（Z〉4.273, P〈0.001）. Conclusion The increase of serum S-100β protein may help assessing early impairment after complete SCI.

关 键 词：脊髓损伤 S-100Β蛋白 血清 生物标记物 

分 类 号：R651.2[医药卫生—外科学]