正交试验优化穿心莲注射液制备工艺  

Optimization Preparation Process of Chuanxinlian Injection by Orthogonal Design

作　　者：霍保军 杨琴 刘鑫 姜国志 

机构地区：[1]神威药业集团有限公司,河北石家庄051430 [2]中药注射剂新药开发技术国家地方联合工程实验室,河北石家庄051430

出　　处：《亚太传统医药》2016年第15期45-47,共3页Asia-Pacific Traditional Medicine

基　　金：石家庄高端医药产业园区创新药物孵化基地(2011ZX09401-306-004)

摘　　要：目的:优选穿心莲注射液的制备工艺。方法:采用紫外分光光度法测定总内酯含量,通过正交实验探索穿心莲注射液的最佳制备工艺。结果:提取温度对收率有显著影响,浓缩效率对收率及含量均有显著影响,配制时所调pH影响不大。结论:最优的制备工艺为提取温度80℃、流浸膏浓缩体积1∶4、配制调节pH=7.0。Objective ： Study the optimization preparation Process of Chuanxinlian Injection. Methods ： Ultraviolet spectrophotomet- ric method is used to determine the content of total lactones in Andrographis paniculata,through orthogonal experiment to determine optimized preparation process of chuanxinlain injection. Results：The extracting temperature had significant effect on extract rate. The yield and content were significantly affected by the concentration efficiency. The pH in the preparation process had no obvious effects. Conclusion：The optimized preparation process temperature is 80℃ ,concentrated volume is 1 ： 4,and the pH in the prepa- ration process is 7.0.

关 键 词：穿心莲注射液 正交试验 制备工艺 

分 类 号：R285.5[医药卫生—中药学]