CD133在子宫内膜异位症相关卵巢癌中的表达  

Expression of CD133 in Endometriosis Associated Ovarian Carcinoma

作　　者：周俭[1] 刘颂平[2] 田鑫[2] 温坚[2] 

机构地区：[1]常州市中医医院,213000 [2]江苏大学附属第四医院,镇江212000

出　　处：《医学研究杂志》2016年第8期80-82,共3页Journal of Medical Research

基　　金：江苏省自然科学基金资助项目(BK20140502);江苏省"六大人才高峰"基金资助项目

摘　　要：目的探讨CD133在子宫内膜异位症相关卵巢癌(endometriosis associated ovarian carcinoma,EAOC)中的表达和意义。方法采用免疫组织化学法检测25例EAOC患者(EAOC组)、22例卵巢子宫内膜异位囊肿(EMs组)中CD133蛋白的表达。结果 CD133在EAOC组中的阳性表达率明显高于EMs组,差异有统计学意义(P<0.05)。EAOC组中CD133的表达与病理分化程度及分期有关,低分化、Ⅲ、Ⅳ期组CD133表达阳性率明显高于中、高分化和Ⅰ、Ⅱ期组(P<0.05)。结论 CD133可能与卵巢子宫内膜异位症恶变的发生、发展有关。Objective To investigate the expression and significance of CD133 in Endometriosis Associated Ovarian Carcinoma （ EAOC）. Methods The protein expression of CD133 was detected with immunohistochemistry in 25 cases of endometriosis associated ovarian carcinoma （EAOC group） and 22 cases of endometriosis（ EMs group）. Results The positive rate of CD133 expression in EAOC group was significantly higher than that in EMs group （P 〈 0.05）. The expressions of CD133 was correlated to pathological classification and staging of EAOC,which in G3, stage Ⅲ or stage Ⅳ was significantly higher than G1 or G2, stage Ⅰ or stage Ⅱ （P 〈 0. 05）. Conclusion The expressions of CD133 might be involved in malignant transformation of ovarian endometriosis.

关 键 词：CD133 子宫内膜异位症 恶变 干细胞 

分 类 号：R711.71[医药卫生—妇产科学]