HIV感染/AIDS患者合并带状疱疹选择膦甲酸钠注射液治疗的疗效观察  

Clinical effectsof foscarnet sodium injection on human immunodeficiency virus- infected or AIDSpatients combined with herpeszoster

作　　者：屈园园[1] 路庆丽[1] 康晓静[1] 

机构地区：[1]新疆维吾尔自治区人民医院皮肤科,乌鲁木齐830001

出　　处：《新疆医学》2016年第5期534-537,共4页Xinjiang Medical Journal

摘　　要：目的对比人类免疫缺陷病毒（Human Immunodeficiency Virus,HIV）感染/艾滋病（Acquired Immune Deficiency Syndrome,AIDS）患者合并带状疱疹选择膦甲酸钠注射液与干扰素治疗的效果。方法选取新疆自治区人民医院皮肤科2008年2月~2013年12月HIV感染/AIDS患者合并带状疱疹90例,随机分为治疗组与对照组各45例,两组都给予基础治疗（包括口服盐酸伐昔洛韦300 mg/次,2次/日;维生素B1 10 mg,3次/日）,然后对照组给予干扰素300万U肌注,1次/日,治疗组给予膦甲酸钠注射液3.0 g静点,2次/日。两组都以7 d为一个疗程,连续治疗2个疗程后观察比较不同治疗后的临床疗效、疼痛、炎症免疫因子的变化情况。结果治疗结束后经过判断,治疗组与对照组的有效率分别为95.6%和80.0%,治疗组的有效率明显高于对照组（P〈0.05）。治疗前两组的疼痛评分对比差异都无统计学意义,治疗组治疗结束与治疗结束2周后的疼痛评分都明显低于对照组（P〈0.05）,同时也都明显低于治疗前,对比差异都有统计学意义（P〈0.05）。两组治疗结束与治疗结束2周后的CD4＋个数、白细胞介素-2（interleukin-2,IL-2）含量明显增加,与治疗前对比差异明显（P〈0.05）,同时治疗组的CD4＋与IL-2与对照组对比差异也有统计学意义（P〈0.05）。结论 HIV感染/AIDS患者合并带状疱疹比较常见,采用膦甲酸钠治疗效果显著。Objective To compare the clinical effects of foscarnet sodium injection and interferon on human immunodeficiency virus （HIV）-infected or AIDS patients combined with herpes zoster. Methods A total of 90 HIV infection/AIDS patients with herpes zoster in department of dermatology of People＇s Hospital in Xinjiang from February 2008 to December 2013 were selected as research objects, who were randomized into treatment group and control group, with 45 patients in each group. Both groups were given basic treatment （oral administration of valaciclovir hydrochloride 300 mg, twice per day; vitamin B1 10 mg, three times per day）. Control group was given interferon 3000000 U by intramuscular injection, once per day while treatment group was given foscarnet sodium 3.0 g by intravenous drip, twice per day. Seven days was a course of treatment for both groups. After continuous 2 courses of treatment, clinical efficacy and changes in the pain and inflammatory immune factors were compared. Results After treatment, effective rates of treatment group and control group were 95.6% and 80.0%, respectively, and the effective rate of treatment group was significantly higher than that of control group （P〈0.05）. Before treatment, there was no significant difference between two groups in pain score; while after treatment and 2 weeks after treatment, pain score in both groups were all decrease （P〈0.05）, and the pain score of treatment group was significantly lower than that of control group （P〈0.05）. After treatment and 2 weeks after treatment, the amount of CD4＋ and content of interleukin-2 （IL-2） were significantly increased in both two groups compared with those before treatment （P〈0.05）, and there was also significant difference between treatment group and control group in the amount of CD4＋ and content of IL-2 （P 〈0.05）. Conclusion HIV/AIDS-infected patients are prone to suffering from herpes zester. Foscarnet sodium was effective to cure it.

关 键 词：HIV感染 获得性免疫缺陷综合征 带状疱疹 膦甲酸钠 干扰素 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]