不同的降血糖治疗方案对无眼底并发症的糖尿病患者黄斑部视网膜厚度的影响  

Effects of different antidiabetic therapies on the macular thickness in diabetes patients without fundus complication

作　　者：王静波[1] 张琳[1] 

机构地区：[1]解放军第309医院眼科,中国北京市100091

出　　处：《国际眼科杂志》2016年第8期1541-1542,共2页International Eye Science

基　　金：国家自然科学基金(No.81100684);首都卫生发展科研专项(No.首发2011-5007-02);总参军事医学和老年病科研基金项目(No.ZCWS14C19)~~

摘　　要：目的:观察不同的降血糖治疗方案对于无眼底并发症的糖尿病患者的黄斑部视网膜厚度的影响。方法:通过频域光相干断层扫描仪检测患者的黄斑部视网膜的厚度,以黄斑为中心进行容积扫描,生成1、3、6mm三个环九个区域的平均厚度数据,并进行统计学分析。结果:研究纳入健康对照组、口服降血糖药物组、胰岛素治疗组三组患者,各组均为22例22眼。健康对照组黄斑区各环视网膜厚度分别为:第1环268.09±17.97μm,第2环340.41±22.25μm,第3环298.14±12.90μm。口服降血糖药物治疗组黄斑区各环视网膜厚度分别为:第1环260.00±18.17μm,第2环335.44±21.12μm,第3环295.63±15.92μm。胰岛素治疗组黄斑区各环视网膜厚度分别为:第1环271.01±26.09μm,第2环340.86±17.10μm,第3环298.57±12.14μm。三组黄斑区第1环视网膜厚度的差异无统计学意义(F=1.21,P=0.31),第2环的差异无统计学意义(F=0.35,P=0.71),第3环的差异亦无统计学意义(F=0.22,P=0.81)。结论:与健康者相比,口服降糖药物和胰岛素治疗均未改变无眼底并发症的糖尿病患者的黄斑区视网膜厚度。AIM： To observe the effects of different antidiabetic therapies on m acular thickness in diabetes patients without fundus com plication.METHODS： The macular thickness was measured by optical coherence tom ography（ OCT）. The retina volum e on the center of m acula was scanned,and it generated autom atically the average thickness data of three rings and nine areas of 1m m,3m m and 6m m. The data were statistically analyzed.RESULTS： Healthy control group,oral hypoglycemic drug group and insulin treatm ent group were enrolled.Each group included 22 cases 22 eyes. The m acular retinal thickness of healthy control group is 268. 09±17. 97μ m（ the1string）,340. 41 ± 22. 25μ m（ the 2ndring） and 298. 14 ±12. 90μ m（ the 3rdring）, respectively. The m acular thickness of oral hypoglycem ic drug group is 260. 00 ±18. 17μ m（ the 1string）,335. 44 ± 21. 12μ m（ the 2ndring）and 295. 63 ± 15. 92μ m（ the 3rdring）,respectively. The m acular thickness of insulin therapy group is 271. 01 ±26. 09μ m（ the 1string）,340. 86 ± 17. 10μ m（ the 2ndring）and 298. 57 ± 12. 14μ m（ the 3rdring）, respectively.Com parison of the m acular thickness of the 1string am ong3 groups was insignificant（ F= 1. 21,P= 0. 31）,neither the com parison of the 2ndring（ F= 0. 35,P= 0. 71）,neither the com parison of the 3rdring（ F= 0. 22,P= 0. 81）.CONCLUSION： Compared with healthy individuals,both oral antidiabetic m edicines and insulin therapy don＇t alter the m acular thickness of patients with diabetes while without fundus com plication.

关 键 词：糖尿病 胰岛素 黄斑 厚度 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]