3,6-二溴-9-(4-溴苯基)-9H-咔唑的合成  

Synthesis of 3,6-Dibromo-N-(4-bromo-phenyl)-9H-carbazole

作　　者：张海涛 左洪亮 许汉 

机构地区：[1]中昊(大连)化工研究设计院有限公司,辽宁大连116023

出　　处：《精细化工中间体》2016年第3期39-41,共3页Fine Chemical Intermediates

摘　　要：以咔唑为原料,经两步反应和一锅法分别合成目标产物3,6-二溴-9-(4-溴苯基)-9H-咔唑。N-芳基化反应和N-溴代丁二酰亚胺(NBS)的亲电取代反应均采用N,N-二甲基甲酰胺做溶剂,并使用将反应母液加入甲醇的方法,以69.6%的收率得到目标产物3,6-二溴-9-(4-溴苯基)-9H-咔唑。3,6-Dibromo-9-（4-bromophenyl）-9H-carbazole was synthesized vis one-pot and two-step reactions using carbazole as the raw material. DMF was used as N-arylation and NBS electrophilic substitution reaction solvent, and methanol was added to the reaction mother liquor to obtain a higher yield of the desired product. A typical total yield of 69.6% was obtained.

关 键 词：咔唑 N-芳基化反应 4-溴碘苯 N-溴代丁二酰亚胺 

分 类 号：TQ251.35[化学工程—有机化工]