帕瑞昔布钠及右美托咪定对老年病人术后认知功能的影响  

Effect of parecoxib sodium and dexmedetomidine given for postoperative cognitive function in elderly patients

作　　者：王丽[1] 

机构地区：[1]商丘市第一人民医院麻醉科,河南商丘476100

出　　处：《医药论坛杂志》2016年第5期39-40,共2页Journal of Medical Forum

摘　　要：目的分析帕瑞昔布钠及右美托咪定对老年患者术后认知功能的影响。方法选取2014年2月—2015年8月收治的99例需手术的老年患者,根据应用药物的不同将患者随机均分为三组,研究组1患者麻醉诱导以静脉注射40mg帕瑞昔布钠,研究组2患者气管插管以静脉泵入0.3μg/(kg·h)右美托咪定,对照组患者则静脉注射等量生理盐水,对比三组患者术后认知功能障碍发生率,并采取简易精神状态量表(MMSE)评估患者术前、术后1d、3d认知功能。结果术前三组患者MMSE均相当(P>0.05),术后1d、3d各组评分均下降,对照组下降程度最大,差异具有统计学意义(P<0.05),而研究组1与研究组2患者术后1d、3d评分相当,差异无统计学意义(P>0.05);对照组患者认知功能障碍发生率为21.21%,研究组1为3.03%,研究组2为6.06%,对照组患者发生率均高于其余两组,差异具有统计学意义(P<0.05),而研究组1与2发生率相当,差异无统计学意义(P>0.05)。结论帕瑞昔布钠与右美托咪定均可降低老年患者手术后认知功能障碍发生率,安全可靠,具有较高临床推广及应用价值。Objective To analyze the impact of parecoxib sodium and dexmedetomidine given to elderly patients with postoperative cognitive function. Methods In our hospital in February 2014 - August 2015 were treated 99 patients re- quired surgery in elderly patients, depending on the application of the drug patients were randomly divided into three groups, Group 1 study in patients with induction of anesthesia with intravenous Dynastat 40rag sodium cloth, study group 2 patients intubated with intravenous infusion of 0. 3 ug/（ kg·h） dexmedetomidine set, the control group of patients in- travenous saline, compared to three groups of patients with postoperative cognitive dysfunction rate and take the Mini - mental state Examination （MMSE） to assess preoperative and postoperative 1 d, 3d cognitive function. Results There were three groups of patients were quite MMSE （P 〉 0. 05）, postoperative l d, 3d scores decreased in each group, the largest decline in the extent of the control group, P 〈 0. 05, the difference was statistically significant, and the Study group 1 and study group 2 postoperative ld, 3d quite score, the difference was not statistically significant （P 〉 0. 05 ） ; cognitive dysfunction rate was 21.21% in the control group, the study group 1 was 3.03% , the study group 2 was 6.06% in the control group patients were higher than the other two groups, P 〈 0. 05, the difference was statistically sig- nificant, but the study group 1 and 2, the incidence considerably, the difference was not statistically significant （P 〉 0.05 ）. Conclusion Parecoxib sodium and dexmedetomidine given in elderly patients after surgery can reduce cognitive dysfunction incidence, safe and reliable, and has a high clinical value.

关 键 词：老年病人 术后 认知功能 帕瑞昔布钠 右美托咪定 

分 类 号：R614[医药卫生—麻醉学]