巨幼细胞性贫血患者血清同型半胱氨酸与精神症状关系的研究  

The relationship between Homocysteine and mental symptoms in megaloblastic anemia patientscaused mental symptoms analysis of the causes

作　　者：邱虹[1] 马风红[1] 梁玉华[1] 尚硕红[1] 

机构地区：[1]宁夏银川市第一人民医院血液科,宁夏银川750001

出　　处：《宁夏医学杂志》2016年第7期611-613,共3页Ningxia Medical Journal

摘　　要：目的探讨巨幼细胞性贫血患者出现精神症状的临床特征及病因。方法选取82例巨幼细胞性贫血(MA)患者,按照有无精神症状分为2组,比较2组患者同型半胱氨酸的含量。结果出现精神症状的患者血清同型半胱氨酸的含量明显增高,血清同型半胱氨酸含量与症状呈正相关性(P<0.05)。MA患者中维生素B12及叶酸缺乏的不同,所表现的精神症状也有差异,维生素B12缺乏以精神症状为主,叶酸缺乏以感觉异常多见。结论 MA患者血清中同型半胱氨酸水平明显增高,是导致患者出现精神神经症状的因素之一。Objective To explore the relationship between homocysteine and mental symptoms in megaloblastic anemia patients. Methods 82 cases of megaloblastic anemia patients were selected. According to the presence of mental symptoms, the patients were divided into two groups. The levels of homocysteine in serum were compared between two groups. Results The homocysteine in ser- um obviously increased in the megaloblastic anemia patients with mental symptoms. Both have positive correlation （ P 〈 0.05 ）. The lacks of VB-2 and folio acid in patients had difference mental symptoms. The patients who lacked of VB-2 were with predominantly mental symp- toms. The patients who lacked of folie acid was of paresthesia. Conclusions The levels ofhomocysteine significantly increased in megaloblastic anemia patients isone of the factors that lead to mental symptoms.

关 键 词：巨幼细胞性贫血 精神症状 同型半胱氨酸 

分 类 号：R556[医药卫生—血液循环系统疾病]