甲亢兔牙槽骨与全身骨密度变化的相关性研究  

Correlation between Changes of Alveolar Bone and Systematic Bone Mineral Density in Hyperthyrosis Rabbits

作　　者：张翔 曲哲 徐晶 马岚 潘小青 张丹迪 

机构地区：[1]大连市口腔医院种植科,辽宁大连116021

出　　处：《口腔医学研究》2016年第7期704-706,共3页Journal of Oral Science Research

基　　金：大连市卫生局资助项目(编号:YWKY-2012059)

摘　　要：目的:比较甲亢兔牙槽骨骨密度和全身骨密度的改变。方法:将24只新西兰大白兔分成两组,每组12只(实验组,对照组),每组雌雄各半。实验组每日用左旋甲状腺素50μg/kg·d-1,生理盐水稀释,腹腔注射,对照组每日注射等量生理盐水。8周后进行FT3、FT4、ALP、Ca、P、Mg检测;用双能X线骨密度扫描仪对腰椎、下颌骨及双侧股骨远心端进行骨密度(BMD)检测。结果:在给药8周后,实验组FT3、FT4、ALP、Ca、P、Mg、BMD数值与对照组比较,具有统计学意义。实验组兔牙槽骨骨密度低于对照组,腰椎,股骨骨密度低于对照组。结论:甲亢兔牙槽骨骨密度变化与全身骨密度变化一致,呈骨质疏松状态,低于正常组。Objective：To compare the changes of alveolar bone and systemic bone mineral density（BMD）of hyperthyrosis rabbits.Methods：Twenty-four New Zealand rabbits were devided into experiment group and control group equally,with half male and half female.Experiment group rabbits were daily injected intraperitoneally with50μg/kg levothyrocine diluted by physiological saline solution.Control group rabbits were daily injected intraperitoneally with the same volume physiological saline solution only.FT3,FT4,ALP,Ca,P,Mg,BMD test were given to both groups after 8weeks.Dual energy X-ray absorptionmetry（DEXA）was used to scan the lumbar vertebra,mandibular,bilateral distal femur for the BMD test.Results：After 8weeks injection,the difference of FT3,FT4,ALP,Ca,P,Mg,BMD level was significant between experimental group and control group.The numerical changes of FT3,FT4 met the diagnostic criteria for hyperthyrosis,and numerical changes of BMD met the diagnostic criteria for osteoporosis.The BMD of mandibular alveolar bone of hyperthyrosis rabbits was lower than the control group.Conclusion：The BMD of mandibular alveolar bone,lumbar spine and femur in the hyperthyrosis rabbits were lower than the control group.Changes of mandibular alveolar bone density in hyperthyrosis rabbits was in line with the lumbar spine and femur,s.

关 键 词：甲亢 下颌牙槽骨 骨密度 兔 

分 类 号：R581.1[医药卫生—内分泌] R783.6[医药卫生—内科学]