耐碳青霉烯类鲍曼不动杆菌的感染分布及耐药性分析  

Analysis on distribution and drug resistance of carbapenem-resistant Acinetobacter baumannii infections

作　　者：何磊[1] 李春华 姜道彬 

机构地区：[1]重庆医科大学公共卫生与管理学院,重庆400016 [2]重庆市大足区人民医院感染管理科,重庆402360

出　　处：《重庆医学》2016年第21期2966-2968,2972,共4页Chongqing medicine

基　　金：重庆市卫生局重点项目(20141024)

摘　　要：目的了解耐碳青霉烯鲍曼不动杆菌(CRAB)感染的分布情况及其对常用抗菌药物的耐药性,为该地区感染控制和合理使用抗菌药物提供依据。方法回顾性分析2013年1月1日至2014年12月31日该院分离的CRAB感染患者的临床资料与药敏结果。结果分别分离社区和医院CRAB感染菌株18、140株,对哌拉西林/他唑巴坦、庆大霉素和妥布霉素的耐药率均高于80%;对氨苄西林/舒巴坦、左氧氟沙星的耐药率分别为64.5%和48.2%;对复方磺胺甲噁唑和阿米卡星的耐药率低于25%,且社区和医院感染CRAB菌株的药敏结果分布比较,差异无统计学意义(P>0.05)。结论 CRAB感染主要以医院感染为主,经验治疗时可选择阿米卡星和复方磺胺甲噁唑。Objective To investigate the distribution of carbapenem-resistant Acinetobacter baumannii（CRAB）infections and its resistance to commonly used antibacterial drugs to provide a basis for infection control and rational use of antibacterial drugs in this area.Methods The clinical data and drug susceptibility test results in the patients with CRAB infection in our hospital from January 1,2013 to December 31,2014 were retrospectively analyzed.Results Eighteen strains of CRAB in community-acquired infection and 140 strains of CRAB in nosocomial infection were isolated,the resistance rates to piperacillin/tazobactam,gentamicin and tobramycin were higher than 80%,which to ampicillin/sulbactam and levofloxacin were 64.5% and 48.2% respectively,which to compound SMZ and amikacin were lower than 25%.The distribution of drug sensitivity results had no statistical difference between community CRAB infection and nosocomial CRAB infection（P〈0.05）.Conclusion The CRAB infection is mainly nosocomial infection,the empirical therapy could select compound SMZ and amikacin.

关 键 词：耐碳青霉烯鲍曼不动杆菌 社区感染 医院感染 耐药性 

分 类 号：R446.5[医药卫生—诊断学]