健脾生血颗粒对骨髓抑制性贫血模型小鼠的治疗作用  

Therapeutic effects of Jianpi Shengxue Granules on mice with myelopathic anemia

作　　者：赵刚 黄志军 吕承恬 李春福[2] 王卫星 郭小娟 熊富良[2] 张雪琼[2] 

机构地区：[1]健民药业集团儿童药物研究院,湖北武汉430052 [2]武汉理工大学化学化工与生命科学学院,湖北武汉430070

出　　处：《中国医院药学杂志》2016年第14期1173-1176,共4页Chinese Journal of Hospital Pharmacy

基　　金：武汉市科技计划项目(编号:200951624496)

摘　　要：目的:探讨健脾生血颗粒对骨髓抑制性贫血模型小鼠的治疗效果。方法:采用Co60照射及腹腔注射环磷酰胺的方法,制备小鼠骨髓抑制性贫血模型。造模成功后,每组小鼠分别灌胃健脾生血颗粒、健脾生血浸膏、硫酸亚铁、生理盐水。3周后,考察外周血象(白细胞、红细胞)及白细胞介素-2水平。结果 :治疗后,实验组小鼠WBC、RBC均高于对照组,同时健脾生血颗粒组小鼠白细胞介素-2水平明显高于其余各组。结论:健脾生血颗粒、健脾生血浸膏、硫酸亚铁均可改善小鼠骨髓抑制性贫血状况,健脾生血颗粒效果明显优于其余各组。OBJECTIVE To investigate the effects of Jianpi Shengxue Granules on mice with myelopathic anemia.METHODS Animal models of mice with myelopathic anemia were made by injecting cyclophosphamide intraperitoneally.Mice in the control group were fed with deionized water.Other groups of mice were given Jianpi Shengxue Granules,ferrous sulfate and traditional Chinese medicine extract,respectively.RBC,WBC and interleukin-2 were measured 3 weeks later.RESULTS After treatment,RBC and WBC in three experimental groups were obviously higher than those in control group,IL-2 of rats fed with Jianpi Shengxue Granules was obviously higher than those in other groups.CONCLUSION Myelopathic anemia can be effectively treated by Jianpi Shengxue Granules.

关 键 词：健脾生血颗粒 骨髓抑制性贫血 红细胞 白细胞 白细胞介素-2 

分 类 号：R96[医药卫生—药理学]