细菌的噬菌体感染耐受机制研究进展  

Advances in research on bacterial resistance mechanisms against bacteriophages

作　　者：肖丽生 祁芝珍[3] 宋亚军[1,2] 

机构地区：[1]安徽医科大学,合肥230032 [2]军事医学科学院微生物流行病研究所，病原微生物生物安全国家重点实验室,北京100071 [3]青海省地方病预防控制所,西宁811602

出　　处：《军事医学》2016年第7期606-609,共4页Military Medical Sciences

基　　金：国家自然科学基金面上资助项目(31360034;31470138)

摘　　要：噬菌体是能感染细菌的病毒,在自然界中分布十分广泛。随着发酵工业中的噬菌体污染以及多药耐药菌株的出现,噬菌体越来越受到关注。噬菌体感染细菌包括吸附、注入、复制、组装、释放等环节;细菌在与噬菌体的共进化过程中,针对这些环节产生了不同的抗感染机制。该文围绕抗吸附、超感染排斥、限制修饰系统、CRISPR系统、流产感染、组装感染等细菌的噬菌体感染耐受机制研究进行了简要综述。Bacteriophages are abundantly distributed viruses,which are able to infect bacteria. Bacteriophages are becoming a focus of attention for microbiologists,as they can cause pollution to the fermentation industry and might serve as alternative therapies for antibiotic-resistant pathogenic bacteria. Effective bacteriophage infection normally involves adsorption,injection,replication,assembly and release,against which bacteria have developed various resistance strategies. The research progress in the bacteriophage resistance mechanisms is briefly reviewed in this paper.

关 键 词：细菌 噬菌体 超感染排斥 限制修饰系统 流产感染 

分 类 号：R37[医药卫生—病原生物学]