天然小分子、表象药理与药物作用的机制  

Natural Small Molecules and Their Phenotype Pharmacology and Mechanisms of Drug-Action

作　　者：雷帆[1,2] 邢东明[1] 严孝金[1] 杜力军[1] 

机构地区：[1]清华大学生命科学学院药物药理实验室,北京100084 [2]清华大学药学院,北京100084

出　　处：《世界科学技术-中医药现代化》2016年第6期1000-1004,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委青年基金项目(30801523):石榴叶总酚成分对脑缺血过程中PPARγ转录活性的影响及其脑保护作用研究;负责人:雷帆;国家自然科学基金委面上项目(81374006):基于小檗碱作为DNA插入子探讨其对正常与缺血再灌神经元基因转录作用差异的机制;负责人:邢东明;国家自然科学基金委面上项目(81073092):从G0/G1期启动探讨小檗碱及黄连对缺血再灌损伤神经元保护作用的位点;负责人:杜力军

摘　　要：本文主要从天然(中药)小分子与化学合成小分子的理念异同、表象药理与特异性靶点及其作用机制的异同等方面对该类小分子成分的特点及其相关的药理学研究的一些概念进行了探讨。由于天然(中药)小分子来源的非目的性,具有体内作用靶点多样性和作用机制广泛性的特点。因此,在药理研究中,要进行相关作用靶点背景的筛选,以确定作用靶点和作用机制的相关性。最后进行作用靶点和作用机制特异性的确证。为了更好的理解和掌握小分子作用的相关性和特异性,进而促进天然(中药)小分子新药的研究,本文对此进行了较为系统深入的探讨。This report discussed internal characteristics and its related pharmacological researches in natural small molecules（traditional medicines）, by comparing with similarities and differences in their concepts, phenotype pharmacological characteristics, specific targets and action mechanisms between natural small molecules and synthetic compounds. Natural small molecules often represented three specific features： unexpected discovery, internal target diversity and multiple mechanisms of action. Therefore, in the pharmacological study of natural small molecules, related targets screening must be performed to determine the correlations of the targets and mechanisms, and finally to identify their specificity. In this report, a systematic in-depth discussion on natural small molecures was pressed ahead with for better understanding and to grasp the correlations and the specificity of natural small molecular actions, which may promote the new-drug discovery and development from natural small molecules（traditional Chinese medicines）.

关 键 词：天然药物 小分子 表象药理学 新药研发 

分 类 号：R96[医药卫生—药理学]