159例原发性高血压病合并靶器官损害患者脉图参数分析  

Analysis of Pulse Parameters Among 159 Primary Hypertension Patients with Target Organ Damage

作　　者：尚倩倩[1] 王蕾[1] 陈兆善[2] 郭睿[1] 王忆勤[1] 燕海霞[1] 

机构地区：[1]上海中医药大学基础医学院,上海201203 [2]上海中医药大学附属市中医医院,上海200071

出　　处：《世界科学技术-中医药现代化》2016年第6期1033-1039,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委青年科学基金项目(81102729):基于脉搏波传播与反射理论的中医脉象特征提取及分类识别研究;负责人:燕海霞;国家自然科学基金委面上项目(81473594):基于血液动力学原理和方法的中医脉象分析与血管功能状态评价研究;负责人:燕海霞;国家自然科学基金委青年科学基金项目(81302913):基于心血管系统电网络模型的冠心病不同证型脉象仿真及形成机理研究;负责人:郭睿;上海市科委自然科学基金(11ZR1436600):基于中医脉象特征分析的高血压患者血管弹性功能评价研究;负责人:燕海霞;上海市科委技术标准专项(14DZ0500400):中医四诊信息采集与分析标准体系研发;负责人:王忆勤;上海市科委专项(13DZ2261000):上海市健康辨识与评估重点实验室;负责人:王忆勤;上海市科委青年科技英才扬帆计划(15YF1412100):基于多标记算法探讨高血压中医风险预警和评估模型;负责人:徐璡

摘　　要：目的:本研究主要探讨原发性高血压病合并不同靶器官损害患者脉图时域参数的变化规律。方法:应用ZBOX-Ⅰ型中医脉象数字化分析仪记录159例原发性高血压病病患者和65例正常人的脉图,比较原发性高血压病合并心、肾、血管等不同靶器官损害患者以及原发性高血压病病合并单器官损害、两器官损害、三器官损害患者脉图时域参数的差异。结果:原发性高血压病病心脏损害组、肾脏损害组、血管损害组脉图参数h_3、h_4、h_3/h_1、w/t明显高于健康对照组(P<0.05);原发性高血压病合并心脏损害组、肾脏损害组、血管损害组脉图参数h_5明显低于健康对照组(P<0.05)。原发性高血压病合并肾脏损害组、血管损害组脉图参数h_3/h_1、h_4/h_1、w/t明显高于心脏损害组(P<0.05);原发性高血压病并肾脏损害组脉图参数h_1、h_3、h_5明显高于心脏损害组(P<0.05);原发性高血压病并血管损害组脉图参数h_5明显低于心脏损害组(P<0.05)。原发性高血压病并两器官损害组脉图参数h_1、h_3、h_4明显低于单器官损害组(P<0.05);原发性高血压病并三器官损害组脉图参数h_4/h_1、h_3/h_1明显低于单器官损害组(P<0.05);原发性高血压病并两器官损害组脉图参数w/t明显高于单器官损害组(P<0.05)。结论:原发性高血压病患者不同靶器官损害患者脉图参数能反映其动脉粥样硬化、外周阻力增大的特点;原发性高血压病患者靶器官损害数量增加,脉图参数呈现相应变化。中医脉图参数可为原发性高血压病靶器官损害的诊断和防治提供参考。This study aimed to investigate the law of pulse parameters among 159 primary hypertension patients with different target organs damage. Pulse graphs of 159 primary hypertension cases and 65 healthy subjects were record with the instrument ZBOX-I designed by Shanghai University of Traditional Chinese Medicine（TCM）. Pulse parameters of patients with different target organs damage, such as heart, kidney and blood vessels, were compared; so were those with single target organ damage, two and three target organs damage. As a result, it was found that pulse figure parameters, including h_3, h_4, h_3 / h_1, w/t in the heart damage in primary hypertension group（the heart damage group）, the renal damage group and the vascular lesions group were higher than those in the control group（P〈0.05）. The pulse figure parameter h_5 in the heart damage group, the renal damage group and the vascular lesions group showed lower levels compared with the control group（P〈0.05）. The pulse diagram parameters, h_3, h_4 / h_1 and w/t, in the renal damage group and the vascular lesions group presented higher levels compared with the heart damage group（P〈0.05）. The pulse graph parameters, h_1, h_3, h_5, in the renal damage group were significantly higher than those in the heart damage group（P〈0.05）. The pulse graph parameter, h_5, in the vascular lesion group was significantly lower than that in the heart damage group（P〈0.05）. The pulse graph parameters, h_1, h_3 and h_4, in the two organ damage group showed lower levels compared with those in the single organ damage group（P〈0.05）. The pulse graph parameters, h_4 / h_1 and h_3 / h_1 in the three organ damage group presented lower levels compared with the single organ damge group（P〈0.05）. The pulse graph parameter, w/t, in the two organ damage group was significantly higher than that in the single organ damage group（P〈0.05）. It was concluded that pulse graph parameters of primary hypertensive patients with target organ damage reflected the

关 键 词：原发性高血压病 靶器官损害 脉象 血管弹性 

分 类 号：R241[医药卫生—中医诊断学]