不同部位注射重组人白介素的效果比较  

Comparison of different injection sites effects for recombinant human interleukin

作　　者：綦菊萍[1] 杨明玉[1] 于丽[1] 

机构地区：[1]解放军总医院骨科五病区,北京100853

出　　处：《中华现代护理杂志》2016年第3期379-380,共2页Chinese Journal of Modern Nursing

摘　　要：目的 探讨传统的三角肌皮下注射法与腹部皮下注射法在注射重组人白介素的局部反应.方法 采用自身对照研究方法 ,将106例注射重组人白介素的患者按疗程分为两组,1~4疗程采用腹部注射方法 ,为观察组;5~8疗程采用传统三角肌注射方法 ,为对照组,每天注射1次,每疗程14 d.观察患者注射部位疼痛、局部不良反应发生情况.结果 观察组患者中、重度疼痛发生率为22.6%、皮下硬结发生率为14.2%、局部红肿发生率为18.9%,均低于对照组,两组比较差异有统计学意义（χ2值分别为2.80,4.71,5.22;P〈0.05）.结论 长期治疗患者腹部皮下注射法较容易接受,既减轻患者痛苦,又能顺利完成治疗,值得临床推广.Objective To explore the efficacy and side effects of recombinant human interleukin by adopting abdominal subcutaneous injection method and the traditional deltoid subcutaneous injection method. Methods A total of 106 patients were admitted to either intervention group or control group by course of treatment. The patient of control group （5-8 course of treatment） adopted traditional deltoid injection method and the intervention group （1-4 course of treatment） received abdominal injection method （1 times a day and 14 days per course of treatment） . Then we observed the incidence of pain and local adverse reactions in patients with injection sites. Results In the intervention group patients was 22. 6% in the incidence of moderate to severe pain, and 14. 2% subcutaneous scleroma rate, 18. 9% local redness and swelling occurred rate, that all were lower than those of the control group （χ2 = 2. 80, 4. 71, 5. 22;P 〈 0. 05 ）. Conclusions The implementation of abdominal subcutaneous injection can reduce the patient＆#39;s pain, promote successful completion of treatment and deserve further clinical dissemination.

关 键 词：重组人白介素 皮下注射 疼痛 不良反应 

分 类 号：R473.73[医药卫生—护理学]