急性发作期支气管哮喘患者的容积二氧化碳图斜率参数变化  

Change of slope parameters in volumetric capnography of asthma patients at acute episodes

作　　者：齐广生[1] 刘锦铭[2,3] 顾文超[1] 杨文兰[3] 郭建[3] 王英敏[3] 郑卫[3] 徐黎青[3] 

机构地区：[1]上海市浦东新区人民医院呼吸科,上海201299 [2]同济大学附属上海市肺科医院肺循环科,上海200433 [3]同济大学附属上海市肺科医院肺功能科,上海200433

出　　处：《诊断学理论与实践》2016年第3期231-234,共4页Journal of Diagnostics Concepts & Practice

基　　金：上海市浦东新区卫生和计划生育委员会科技发展专项基金资助(PW2015B-14)

摘　　要：目的:探讨容积二氧化碳图(volumetric capnography,VCap)斜率参数对急性发作期支气管哮喘(以下简称哮喘)的诊断价值。方法:对53例急性发作期哮喘患者(哮喘组)及43名健康者(健康组)进行肺通气功能及VCap测定。采用Pearson相关性分析检验肺通气功能与VCap斜率指标间的相关性,采用独立样本t检验比较哮喘组与健康组间的VCap斜率指标差异,并用受试者工作特征曲线(receiver operator characteristic curve,ROC曲线)分析VCap斜率指标对急性发作期哮喘患者与健康人的鉴别效能。结果:Ⅲ相斜率(d C3/DV)、SR23分别与一秒钟用力呼气量(forced expiratory volume in one second,FEV1)占预计值百分比(FEV1/pre)、FEV1/用力肺活量(forced vital capacity,FVC)%呈负相关(P<0.05)。d C2/DV与FEV1/FVC%成正相关(P<0.05)。哮喘组d C3/DV、SR23均较健康组增大,差异有统计学意义(P<0.01)。d C2/DV、d C3/DV和SR23的曲线下面积分别为0.605、0.724、0.757。结论:VCap是一种简便易行的指标,对急性发作期哮喘的诊断具有一定参考价值。Objective： To investigate the diagnostic value of volumetric capnography（VCap） parameters for asthma patients at acute episodes. Methods： VCap and spirometry were performed in 53 asthma patients at acute episodes and 43 healthy subjects. Correlation between VCap slope parameters and spirametory parameters were tested by Pearson analysis.Diagnostic performance of VCap slope for differentiating asthma patients from healthy subjects was evaluated by receiver operator characteristic（ROC） curve. Result： d C3/DV and SR23 were negatively correlated with FEV1/pre and FEV1/FVC%, respectively（P〈0.05）, while d C2/DV was positively correlated with FEV1/ FVC%（P〈0.05）. d C3/DV and SR23 increased significantly in asthma group than those in healthy subjects. ROC curve analysis showed that AUC for d C2/DV,d C3/DV and SR23 were 0.605,0.724 and 0.757, respectively. Conclusions： Change of slope parameters in VCap is a simple method, which could provide references for diagnosing asthma patient at acute episode.

关 键 词：支气管哮喘 容积二氧化碳图 肺功能测定 

分 类 号：R562.25[医药卫生—呼吸系统]