SIRT1在运动防治糖尿病患者骨骼肌胰岛素抵抗中的作用  

Role of SIRT1 Plays to Prevent Insulin Resistance of Skeletal Muscle by Exercise in Diabetic Patients

作　　者：杨雯茜[1] 杨光[1] 郑梅[2] 刘玉倩[1] 王海涛[1] 

机构地区：[1]河北师范大学体育学院,河北石家庄050024 [2]石家庄市第一医院,河北石家庄050011

出　　处：《河北师范大学学报（自然科学版）》2016年第4期362-368,共7页Journal of Hebei Normal University：Natural Science

基　　金：河北省自然科学基金(C2013205026);河北省教育厅重点基金(ZD20131100);河北师范大学重点基金(L2013Z08);河北师范大学体育学重点学科;河北省体育教育训练学重点学科资助;2016年院研究生创新资助

摘　　要：沉默交配型信息调节因子2同源蛋白1(SIRT1)是NAD+依赖的组蛋白去乙酰化酶,参与葡萄糖/脂质代谢、线粒体生物合成、炎症、自噬和生理节律等.最近研究表明,SIRT1在糖尿病发病中发挥重要作用,糖尿病发病率升高与饮食结构的改变和久坐的生活方式密切相关,运动可以通过SIRT1介导的调控通路改善糖尿病患者骨骼肌的胰岛素敏感性,降低胰岛素抵抗.概括了近几年腺苷酸活化蛋白激酶(AMPK),SIRT1,过氧化物酶体增殖物激活受体γ协同刺激因子1α(PGC-1α)在运动防治糖尿病中的研究现状及发展趋势,为通过运动改善骨骼肌代谢功能防治糖尿病提供新的思路.Silent mating type information regulation 2homolog（SIRT1）is a kind of NAD＋-dependent histone deacetylase.It is involved in the glucose/lipid metabolism,mitochondrial biosynthesis,inflammation,autophagy and circadian rhythm,etc.Recent studies have shown that SIRT1 plays a significant role in the incidence of diabetes.The incidence of diabetes is closely related to the diet and sedentary lifestyle.Exercise can be mediated by SIRT1 regulation pathways to improve diabetes skeletal muscle insulin sensitivity and decrease insulin resistance.This paper summarized the research status and development trend of recent years that adenosine 5′-monophosphate-activated protein kinase（AMPK）,SIRT1,peroxisome proliferatoractivated receptor-γcoactivator-1α（PGC-1α）alpha in preventing and controlling of diabetes with exercise,and provides new mentality about improving skeletal muscle metabolism,and prevention and treatment of diabetes through exercise.

关 键 词：运动 糖尿病 骨骼肌 SIRT1 AMPK PGC-1Α 

分 类 号：G804.55[文化科学—运动人体科学]