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作 者:谷园园 邹延峰[1] 徐建华[2] 胡华青[3] 孙秀秀[1] 陶金辉[4] 徐胜前[2] 刘爽[2] 王德光[5] 刘盛秀[6] 蔡静[2] 肖会[2] 陈佩玲[2] 连莉[2] 宋亚平[1] 梁春梅[7] 王中新[8] 黄海良[9] 潘发明[1] 苏虹[1] 潘海峰[1] 叶冬青[1]
机构地区:[1]安徽医科大学公共卫生学院流行病与卫生统计学系,合肥230032 [2]安徽医科大学第一附属医院风湿免疫科,合肥230022 [3]安徽医科大学第一附属医院健康体检中心,合肥230022 [4]安徽医科大学附属省立医院风湿免疫科,合肥230001 [5]安徽医科大学第二附属医院肾内科,合肥230601 [6]安徽医科大学第一附属医院皮肤性病科,合肥230022 [7]安徽医科大学公共卫生学院检验系,合肥230032 [8]安徽医科大学第一附属医院检验科,合肥230022 [9]安徽医科大学生物化学教研室,合肥230032
出 处:《安徽医科大学学报》2016年第8期1151-1155,共5页Acta Universitatis Medicinalis Anhui
基 金:国家自然科学基金(编号:81373073)
摘 要:目的 探讨Hsp90AB1基因多态性与中国汉族人群系统性红斑狼疮(SLE)发病之间的关系。方法 对278例SLE患者和278例正常对照者采用病例对照研究。HapMap数据库和Haploview软件筛选出中国人群Hsp90AB1基因标签SNPs,采用Multiplex SNaPshot技术进行基因分型。运用SPSS10.01软件进行统计分析。应用在线软件进行单倍型统计分析。结果 rs9367190位点的基因型(CC、CA、AA)的频率在SLE组与对照组分布差异无统计学意义(P〉0.0125),而等位基因C、A的频率在SLE组与对照组分布差异有统计学意义(P〈0.0125);采用显性模型(CCvsCA+AA:校正OR=0.649,95%CI:0.464-0.908,P=0.012)分析结果差异有统计学意义,但隐性模型分析结果差异无统计学意义(P〉0.0125)。而rs13296位点的基因型GG、GA、AA的频率以及其等位基因G、A频率在SLE组与对照组的分布均差异无统计学意义(P〉0.0125);显性模型和隐性模型分析结果差异均无统计学意义(P〉0.0125)。单倍型A/G与SLE发病之间存在关联(OR=0.668,95%CI:0.512~0.871,P=0.003)。结论 在中国人群中Hsp90AB1基因多态性(rs9367190)可能和SLE发病关联。Objective To explore the association between Hsp90AB1 gene polymorphism and systemic lupus erythematosus(SLE) susceptibility in Chinese ban population. Methods A case-control study was conducted by 278 SLE patients and 278 normal controls. Hsp90AB1 genetic tag SNPs( single nucleotide polymorphisms) in Chinese population were selected by the HapMap database and Haploview software, and the Tag SNPs were genotyped by Multiplex SNaPshot technology. Statistical analysis was performed with SPSS 10. 01 software. An online software was used in haplotypes analysis. Results The rs9367190 genotypes (CC, CA, AA) had significant difference between SLE group and the control group (P 〉 0. 012 5 ), but the allele (C, A) frequency distribution had significant difference between SLE group and the control group ( P 〈 0. 012 5 ) ; there was significant association between Hsp90AB1 gene rs9367190 polymorphism and SLE under the dominant model analysis(CC vs CA + AA:adjust OR -0. 648, 95 % CI:0. 464 -0. 906, P = 0.011 ), but there was no statistically significant difference of the result in the recessive model analysis (P 〉 0. 012 5 ). However, the genotypes ( GG, GA, AA) and the allele ( G, A) frequency distributions of the rs13296 polymorphism all had no statistically significant difference between SLE group and the control group(P 〉0. 012 5). The results of the dominant model analysis and the recessive model analysis had no significant difference( P 〉 0. 012 5 ). There was an association between SLE and haplotype A/G( OR = 0. 668, 95% CI:0. 512 -0. 871 ,P =0. 003). Conclusion Hsp90AB1 gene polymorphism (rs9367190) may be associated with SLE in Chinese population.
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