中青年人群发生急性心肌梗死的危险因素分析  

Risk Factors Analysis for Prevalence of Acute Myocardial Infarction in Young and Middle-aged Population

作　　者：韩全乐[1] 毛瑞英 郁静 吴寿岭[3] 高竟生[3] 张琦[1] 吴梅玲[4] 张庆华[1] 刘晓明[1] 尚小明[1] 刘晓堃[1] 

机构地区：[1]唐山市工人医院心内科 [2]唐山市工人医院介入科 [3]开滦总医院心内科 [4]中国人民解放军66208部队卫生队

出　　处：《中国循环杂志》2016年第7期632-635,共4页Chinese Circulation Journal

摘　　要：目的：分析中青年人群发生急性心肌梗死（AMI）的相关危险因素。方法：应用前瞻性队列研究,从2012-06至2014-10开滦研究中健康查体人群（n=110 100名,年龄18~98岁）中,按男性≤53岁,女性≤63岁的标准,纳入中青年受试者62 208名,随访2年,以发生AMI为研究终点事件,分析中青年人群发生AMI的危险因素。结果：随访期间,有56名发生AMI,为AMI组,62 152名受试者未发生AMI,为正常组。AMI组受试者的年龄、体重指数（BMI）、收缩压（SBP）、舒张压（DBP）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）水平高于正常组,AMI组的糖尿病病史、服用降压药物的患者比例高于正常组（P均〈0.05）;Cox比例风险回归分析得出：年龄、男性、LDL-C、TG为中青年人群发生AMI的危险因素[危险比（RR）=1.37、60.54、1.12、5.93,P均〈0.05]。结论：年龄、男性、LDL-C、TG为中青年人群发生AMI的危险因素。Objective： To study the risk factors for prevalence of acute myocardial infarction（AMI） in young and middle-aged population.Methods： A prospective cohort study was conducted in 110100 subjects at the age of（18-98） years who received physical examination in Kailuan Group from 2012-06 to 2014-10. Based on the limitations of male≤53 years and female≤63 years, a total of 62367 subjects were enrolled in our study. The subjects were followed-up for 2 years by the end point event of AMI to analyze the risk factors of AMI occurrence.Results： According to AMI occurrence at the follow-up period, the subjects were divided into 2 groups： AMI group, n=56 and Control group, n=62152. Compared with Control group, AMI group had increased BMI, SBP, DBP and elevated blood levels of LDL-C, TG; AMI group also showed the higher ratios of subjects with the history of diabetes and taking anti-hypertension medication. Cox proportional hazard regression analysis indicated that age（RR=1.37）, male（RR=60.54）, LDL-C（RR=1.12）, and TG（RR=5.93） were the risk factors for AMI occurrence in young and middle-aged population, all P〈0.05.Conclusion： Age, male gender, blood levels of LDL-C, and TG were the risk factors for AMI occurrence in young and middleaged population.

关 键 词：急性心肌梗死 危险因素 中青年人群 

分 类 号：R54[医药卫生—心血管疾病]