血尿酸水平与冠心病发病关系的剂量-反应Meta分析  

Meta Analysis for the Relationship Between the Levels of Serum Uric Acid and Prevalence of Coronary Artery Disease

作　　者：芦永斌 程治远[2] 赵亚学 常晓宇[1] 程宁[2] 

机构地区：[1]兰州大学公共卫生学院,甘肃省兰州市730000 [2]兰州大学基础医学院,甘肃省兰州市730000

出　　处：《中国循环杂志》2016年第7期640-643,共4页Chinese Circulation Journal

摘　　要：目的：用Meta分析方法评价血尿酸水平与冠心病发病间的剂量-反应关系。方法：通过数据库（Pub Med,Elsevier和Web of Science）检索已经公开发表的国外关于血尿酸水平与冠心病发病的队列研究。利用Stata软件对其进行综合分析。结果：纳入11项队列研究,463 918例研究对象。在男性和女性中,血尿酸水平增高均是冠心病发病的危险因素,其相对危险度（RR）及其95%可信区间（95%CI）分别为：1.11（1.00-1.24）和1.24（1.15-1.34）。剂量-反应Meta分析：随着血尿酸水平的增加,冠心病发病风险也在逐步增加;血尿酸水平每增加1mg/dl,在男性和女性中冠心病发病风险分别增加4.8%和12.4%,且女性明显高于男性。结论：血尿酸水平与冠心病发病存在密切相关。Objective： To evaluate the relationship between the levels of serum uric acid（SUA） and prevalence of coronary artery disease（CAD） by Meta analysis.Methods： We searched the databases of Pub Med, Elsevier and Web of Science for internationally published cohort study for the relationship between SUA levels and CAD prevalence and conducted a general analysisby using Stata software.Results： A total of 11 cohort study including 463,918 subjects were enrolled in this study. For both male and female genders, increase SUA level was the risk factor for CAD occurrence（RR=1.11, 95% CI 1.00-1.24） and（RR=1.24, 95% CI 1.15-1.34）. Dose-response Meta-analysis indicated that by 1 mg/dl SUA elevation, the risk of CAD occurrence would increase 4.8% in male and 12.4% in female, the risk in female gender was higher than male.Conclusion： SUA level has been closely related to CAD prevalence.

关 键 词：尿酸 冠状动脉疾病 

分 类 号：R54[医药卫生—心血管疾病]