青蒿鳖甲汤现代药理及临床应用研究进展  

Professor ZHANG Yan（张艳）＇s Experience of the Treatment of Chronic Heart Failure

作　　者：胡佳骅[1] 张艳[2] 

机构地区：[1]辽宁中医药大学:2009级本硕中医专业,沈阳110032 [2]辽宁中医药大学附属医院慢病二科,沈阳110032

出　　处：《实用中医内科杂志》2016年第7期1-2,共2页Journal of Practical Traditional Chinese Internal Medicine

基　　金：首都中医药研究专项（1150170204/15ZY06）；国家自然科学基金项目（81573682）

摘　　要：青蒿鳖甲汤出自《温病条辨》,系治疗温病后期阴虚邪伏代表性方剂,内清血中伏热、外透阴分伏邪。对原因不明发热及慢性疾病、肿瘤、血液病、术后消耗性发热,疗效显著,无严重不良反应,广泛应用于内、外、妇、儿等各科疾病。随着老龄化社会和疾病谱变化,邪伏阴分发热成为多种疾病共性证候,对“热自阴来”的发热,存在“夜热早凉,热退无汗”等诸证,无论有无阴虚症状或轻重,均可使用,须“审因论治”,明确系温热病后期,邪伏阴分兼阴虚,灵活加减,阴虚较重加元参养阴滋液;虚热甚加地骨皮清透伏热。药理研究主要集中在白血病,已经证实青蒿鳖甲汤能阻止白血病细胞增殖进程,促进白血病细胞凋亡,降低s TNFαR含量,提高免疫力;促进DC分泌IL-12,增加抗肿瘤作用,其他方面研究较少。未来应深入研究作用机理和应用范围。Professor ZHANG Yan considers that the correlation theory of heart, brain and kidney shall start with the whole view, and the correlation of heart, brain and kidney is mainly reflected in the interlinked blood vessels in which the blood and Qi circulate as well as their interaction in mentality, a broken heart is closely related to ＂ heart governing blood and vessels＂ and ＂heart storing spirit＂ , heart, and moreover, brain and kidney connect with and influence each other. It accords with etiology and pathogenesis to treat chronic cardiac failure based on syndrome differentiation in relation to the ＂Heart-Brain-Kidney Axis＂ , by nursing heart, brain and kidney simultaneously, tonifying the heart, warming the kidney and calming the nerves so as to warm kidney Yang, to rest to attain mental tranquility with sufficient heart Qi, and to maintain a good cardiac function.

关 键 词：青蒿鳖甲汤 吴鞠通 温病条辨 阴虚邪伏 邪伏阴分 热自阴来 发热 夜热早凉 热退无汗 抗肿瘤 白血病 细胞增殖 s TNFαR DC IL-12 中医药治疗 

分 类 号：R289.5[医药卫生—方剂学]