瓜蒌薤白半夏汤合桃红四物汤联合西药治疗痰阻血瘀型胸痹随机平行对照研究  

Randomized Parallel Contrast Study of Joint Effect of Gualou Xiebai Banxia Decoction(瓜蒌薤白半夏汤) and Taohong Siwu Decoction(桃红四物汤) as well as Western Medicine on Phlegm Turbid-Blood Stasis Thoracic Obstruction

作　　者：王士兵[1,2] 

机构地区：[1]海安县中医院心血管内科,江苏海安226600 [2]Department of Internal Medicine the First Clinical Medical College of Shandong University

出　　处：《实用中医内科杂志》2016年第7期52-54,共3页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察瓜蒌薤白半夏汤合桃红四物汤联合西药治疗痰阻血瘀型胸痹疗效。[方法]使用随机平行对照方法,将62例住院及门诊患者按病志号抽签方法简单随机分为两组。对照组31例:阿司匹林、单硝酸异山梨酯、美托洛尔等扩血管、抗血小板、调脂、降压、抗心绞痛等。治疗组31例瓜蒌薤白半夏汤合桃红四物汤(瓜蒌12g,薤白、法半夏各9g,熟地15g,川芎8g,当归15g,赤芍10g,桃仁9g,红花6g),水煎400m L,1剂/d,饭后30min口服,2次/d;西药治疗同对照组。连续治疗7d为1疗程。观测临床症状、心绞痛发作、心电图、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组显效18例,有效11例,无效2例,总有效率93.55%。对照组显效6例,有效16例,无效9例,总有效率70.97%。治疗组疗效优于对照组(P<0.01)。心电图改善治疗组优于对照组(P<0.05)。[结论]瓜蒌薤白半夏汤合桃红四物汤联合西药治疗痰阻血瘀型胸痹,疗效满意,无严重不良反应,值得推广。[Objective] To observe clinic efficacy of Gualou Xiebai Banxia decoction and Taohong Siwu decoction as well as western medicine on Phlegm Turbid-Blood Stasis Thoracic Obstruction. [Methods] the method of Randomized parallel contrast is adopted. 62 cases of patients in hospital or in outpatient service, drawing lots which are their pathography numbers, were randomly divided into treatment group and control group, 31 cases in each group. Patients in control group are asked to take drugs such as aspirin, isosorbide mononitrate, metoprolol with effects of vascular dilation, anti-platelet, lipid regulation, decreasing blood pressure and anti- angina. While patients in the treatment group took Gualou Xiebai Banxia decoction and Taohong Siwu decoction. The Chinese medicinal materials, which are 9 grams Gualou, 9 grams Xiebai, 9 grams Banxia,15 grams Shudi, 8 grams Chuanxiong, 15 grams Chinese angelica, 10 grams red peony root, 9 grams peach kernel, 6 grams safflower, are boiled in 400ml water. A dose of decoction should be taken 30 minutes after dinner, twice per day. Besides, patients in the treatment group also take the same western medicine as those in the control group do. Two groups both received two periods of treatment, each of which lasted 7 days. Patients＇ clinical signs, angina pectoris, electrocardiogram, and untoward effects were observed. Therapeutic effects are evaluated after two successive periods of treatment. [Results] There are18 cases of response in the treatment group with an effectivity of 93.55%, while 6 cases of response in the control group with an effectivity of 70.97%. The control group gained better curative effect than the treatment group（P〈0.01） and better improvements of electrocardiogram （P〈0.05）. [Conclusion] The clinical curative effect of plus administration of Gualou Xiebai Banxia decoction and Taohong Siwu decoction on the basis of regular treatment using western medicines is satisfactory and without severe adverse reactions. The method is worthy of popularization.

关 键 词：胸痹 痰阻血瘀 瓜蒌薤白半夏汤 桃红四物汤 心绞痛 心电图 随机平行对照研究 

分 类 号：R289.5[医药卫生—方剂学]