不同剂量胰岛素治疗小儿糖尿病酮症酸中毒的临床效果分析  

Analysis of the Clinical Effect of Different Doses of Insulin Therapy in Children with Diabetic Ketoacidosis

作　　者：杨威[1] 

机构地区：[1]郑州市儿童医院儿科,河南郑州450000

出　　处：《糖尿病新世界》2016年第14期15-16,共2页Diabetes New World Magazine

摘　　要：目的分析不同剂量胰岛素对小儿糖尿病酮症酸中毒的临床治疗效果。方法选取2014年6月—2015年12月该院收治94例小儿糖尿病酮症酸中毒临床资料进行回顾性分析,根据所用剂量不同分为两组,对照组40给予大剂量胰岛素,研究组54例给予小剂量胰岛素,分析两组治疗效果。结果治疗后两组酸中毒纠正和尿酮体转阴时间、餐后2 h血糖、空腹血糖比较差异无统计学意义(P>0.05);观察组血糖下降幅度(5.3±3.5)mmol/L比对照组(7.5±3.9)mmol/L低,差异有统计学意义(P<0.05)。结论小剂量与大剂量胰岛素治疗小儿糖尿病酮症酸中毒的疗效差异不大,但小剂量胰岛素更能稳定降低血糖,具有实用价值。Objective To analyze the clinical therapeutic effects of different doses of insulin in diabetic ketoacidosis.Methods 94 cases of diabetic ketoacidosis in children clinical data were retrospectively analyzed from June 2014 to 2015 December in our hospital. According to the different dose for two groups, the control group of 40 received a high dose of insulin, research group（54 cases） was treated with small dose of insulin. Analysis the therapeutic effect of two groups. Results After treatment, two groups of acidosis corrective and ketonuria time, postprandial 2H plasma glucose, fasting plasma glucose（FPG） no significant difference（P〈0.05）; observation group, the levels of blood glucose decreased（5.3±3.5）mmol/L than control group（7.5±3.9）mmol/L to low, significant difference with statistical significance（P〈0.05）. Conclusion No significant difference between the efficacy of small dose and large dose of insulin in the treatment of children with diabetic ketoacidosis, but small dose of insulin more stability and reduce the blood sugar, has practical value.

关 键 词：剂量 胰岛素 酮症酸中毒 效果 

分 类 号：R725[医药卫生—儿科]