鄂温克族骨性关节炎患者血浆中21种微量元素分析  

Analysis of 21 types of plasma trace element in Ewenki patients with osteoarthritis

作　　者：唐思思[1] 王声雨[2] 党瑞[1] 吴俊华[3] 高彦辉[3] 陶树清[2] 任小平[2] 王德才[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,哈尔滨150081 [2]哈尔滨医科大学第二附属医院,哈尔滨150086 [3]中国疾病预防控制中心地方病中心,哈尔滨150081

出　　处：《中国骨质疏松杂志》2016年第7期883-887,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81172605)

摘　　要：目的探讨鄂温克族骨性关节炎患者血浆中21种微量元素的含量水平。方法采用0.3 ml HNO_3+0.3 ml H_2O_2混合消解液消化血浆样品,用电感耦合等离子体质谱(ICP-MS)测定血浆中Li、Mg、Al、Ca、Ti、V、Cr、Mn、Fe、Co、Ni、Cu、Zn、As、Se、Sr、Mo、Cd、Ba、Tl、Pb等21种微量元素,用t检验方法统计分析。结果病例组和对照组血浆中6种元素(Ti、V、Ni、As、Mo、Tl)低于方法的定量检出限;其他15种元素均检出,其中,病例组血浆中4种元素Al,Ca,Cr,Cd的含量低于对照组;11种元素Li,Mg,Mn,Fe,Co,Cu,Zn,Se,Sr,Ba,Pb的含量高于对照组,且Co和Pb含量在两组间比较具有统计学意义(P<0.05)。结论鄂温克族骨性关节炎患者血浆中微量元素普遍高于正常对照水平,且Co与Pb元素水平与骨性关节炎患者发病存在潜在的相关性。Obje ctive To investigate the distribution of 21 types of plasma trace element in Ewenki patients with osteoarthritis.Me thods The plasma samples were digested in the mixture of 0. 3 ml of HNO3 and 0.3 ml of H2O2. Plasma Li,M g,Al,Ca,Ti,V,Cr,M n,Fe,Co,Ni,Cu,Zn,As,Se,Sr,M o,Cd,Ba,Tl,and Pb were detected using inductively coupled plasma mass spectrometry（ ICP-M S）. Data were analyzed using t test. Re sults The concentrations of the six elements（ Ti,V,Ni,As,M o,and Tl） were lower than the quantitative detection limit of the method. The levels of Al,Ca,Cr,and Cd in the osteoarthritis patients was lower than those in the control group,while the concentrations of Li,Mg,Mn,Fe,Co,Cu,Zn,Se,Sr,Ba,and Pb were higher than those in the control group. In addition,the levels of Co and Pb were significant different between the two groups（ P〈0. 05）. Conclusion The content of trace elements in Ewenki patients with osteoarthritis is higher than that in control group.The levels of Co and Pb is potentially associated with osteoarthritis.

关 键 词：骨性关节炎 电感耦合等离子体质谱 微量元素 

分 类 号：R684.3[医药卫生—骨科学]