冠心病患者检测血浆氨基末端脑钠肽前体及同型半胱氨酸的临床意义  

The Clinical Significance of Detecting NT- pro BNP and Homocysteine in Patients with Coronary Atherosclerosis

作　　者：石秀芳[1] 孙峰[1] 雷婷[1] 王萍[1] 敖家富[1] 

机构地区：[1]安徽省亳州市人民医院,236800

出　　处：《临床输血与检验》2016年第4期362-364,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探讨冠心病患者检测血浆氨基末端脑钠肽前体及同型半胱氨酸的临床意义。方法根据冠心病严重程度及冠状动脉造影冠脉病变支数分组,分析比较疾病不同程度时血清氨基末端脑钠肽前体及同型半胱氨酸的差异。结果AMI组、UAP组、SAP组及对照组两两比较,NT-pro BNP和HCY水平的差异具有统计学意义(P<0.05);冠状动脉一支病变组、二支病变组、多支病变组两两比较,NT-pro BNP和HCY水平差异具有统计学意义(P<0.05)。冠心病病情程度越重,病变冠状动脉越多,NT-pro BNP和HCY水平升高越明显。结论血清HCY、BNP水平的变化与冠心病疾病严重程度相关,动态监测对于临床指导冠心病的预防、控制具有重要的意义。Objective To study the clinical significance of detecting NT-pro BNP and homocysteine（HCY） in the patients with coronary atherosclerotic heart disease. Methods According to the severity of coronary artery disease and coronary arteriography, 1 1 9 cases were divided into different groups, and 50 healthy persons were used as control group. All cases were individually measured for NT-pro BNP and HCY. Results The levels of NT-pro BNP and HCY in the groups of AMI,UAP, and SAP were significantly higher than those in the control group（P〈0.05）, and the highest levels were noted in AMI group（P〈0.05）. The levels of NT-pro BNP and HCYvaried significantly in the patients with single, double or multiple vessels disease. Conclusion The serum NT-pro BNP and HCY levels are associated with severity of coronary artery diseases. Detection of both serum components is has clinical significance in appropriate treatments of coronary heart disease.

关 键 词：冠心病 氨基末端脑钠肽前体 同型半胱氨酸 

分 类 号：R541.4[医药卫生—心血管疾病] R446.11[医药卫生—内科学]