丙型肝炎感染相关因素的追踪研究  

A follow-up study of hepatitis C infection

作　　者：杨永荣[1] 严晓会[1] 王巧凤[1] 邵艳芳[1] 缪新权[1] 

机构地区：[1]玉溪市人民医院,云南玉溪653100

出　　处：《云南医药》2016年第4期393-395,共3页Medicine and Pharmacy of Yunnan

摘　　要：目的对不同途径丙型肝炎病毒感染患者的预后进行追踪研究,为控制丙型肝炎的传播提供科学依据。方法采用流行病统计学方法,分析224例不同感染途径的丙肝患者10年的预后转归。结果静脉吸毒者115例,不能明确原因感染者80例,其它途径感染29例（嫖娼及卖淫史13例,夫妻互为传播7例,母婴传播6例,输血史3例）。静脉吸毒者、不能明确原因感染者及其它途径的3~5倍ALT上限分别为103（89.6%）例与52（65.0%）例及11（37.9%）例,差异有统计学意义 （P〈0.05）。HCV-RNA 阳性分别为 112 （97.4%） 例与 62 （77.5%） 例及 16 （55.2%） 例,差异有统计学意P〈0.05）。结论吸毒人群中抗 HCV 阳性率远超过自然人群的感染率,加之丙肝的慢性临床表现不容易发现,进展隐匿,慢性率高及随后肝硬化、肝癌而倍受关注,丙型肝炎的发病率有增无减,这必将带来更为严重的后果[1]。学意义（P〈0.05）。HCV-RNA阳性分别为112（97.4%）例与62（77.5%）例及16（55.2%）例,差异有统计学意义（P〈0.05）。结论吸毒人群中抗HCV阳性率远超过自然人群的感染率,加之丙肝的慢性临床表现不容易发现,进展隐匿,慢性率高及随后肝硬化、肝癌而倍受关注,丙型肝炎的发病率有增无减,这必将带来更为严重的后果[1]。Objective A follow-up study to the prognosis of patients with hepatitis C virus（HCV） infection were under taken,in order to provide a scientific basis for controlling the spread of hepatitis C. Methods To use epidemiology methods, for analysing the prognosis and outcome of 224 patients with hepatitis C virus（HCV） infection for 10 years. Results 115 cases of intravenous drug users, un-clear original infection in 80 cases, and other way 29cases（13 cases of prostitution, couples spread in 7 cases, 6 cases of mother-to-child transmission, history of blood transfusion 3 cases）.Patients were individually of（3~5）times the maximum ALT 89.6%,65.0% and 37.9% cases.Using SPSS18.0 software to deal with data（χ2=33.39, P〈0.05）,there were very significant differences. HCV-RNA positives were respectively of 97.4%,77.5% and 55.2% cases.（χ2=37.24, P〈0.05）, the differences were statistically significant.Conclusion Drug users with anti HCV infection are more than that of the natural population. They are not easy to find.The liver cirrhosis and liver cancer increase, it will certainly bring more serious consequences.

关 键 词：丙型肝炎病毒感染 相关因素 追踪研究 

分 类 号：R512.63[医药卫生—内科学]