持续性肝动脉灌注加栓塞治疗肝脏多发转移性病灶的临床应用  

Clinical application of continuous TAI and TACE in the treatment of multiple hepatic metastasis focus

作　　者：杨银山[1] 李定坤[1] 杨卓林[1] 谭骅[1] 赵玲[1] 

机构地区：[1]云南省肿瘤医院微创介入医学科,云南昆明650031

出　　处：《云南医药》2016年第4期396-398,共3页Medicine and Pharmacy of Yunnan

摘　　要：目的探讨持续性肝动脉灌注加栓塞在治疗肝脏多发转移性病灶的临床应用。方法以我院2010年1月-2013年4月我院收治70例原发性肝癌或转移性肝癌患者为研究对象。所有患者均经CT或MRI检查确定存在多发性转移灶。将70例患者随机分为观察组(TACE组)与对照组(TAI组)各35例,对照组选择肝动脉灌注化疗治疗,观察组在对照组前提下,进行肝动脉栓塞化疗治疗。比较两组的近期治疗疗效、近3年的生存率及不良反应发生情况。结果观察组近期治疗有效率为91.4%,对照组为62.9%,组间比较观察组高于对照组(P<0.05)。观察组患者恶心呕吐、白细胞下降、血小板下降、腹泻及胆红素升高的发生率与对照组相比均未见显著性差异(P>0.05)。观察组1年、2年、3年的生存率分别为65.7%、51.4%、31.4%,均高于对照组患者的同期生存率(P<0.05)。结论采用持续性肝动脉灌注加栓塞化疗治疗肝脏多发性转移性病灶可有效控制病灶的发展与扩散,缓解临床症状,延长患者生存期,且安全性较高,可于临床进行推广应用。Objective To explore the clinical application of continuous TAI and TACE in the treatment of multiple hepatic metastasis focus. Methods 70 patients with primary liver carcinoma or metastatic hepatic carcinoma treated from January 2010 to April 2013 in our hospital were selected. CT or MRI examination was applied. The subjects were randomly divided into observation group（TACE group） and control group（TAI group）, 35 cases each group. The control group took TAI; the observation group adopted TAI and TACE. The short-term effect, survivial rate in recent three years and adverse event rate for two groups were compared. Results The short-term effective rate of observation group（91.4%） was higher than that of control group（62.9%）（P〈0.05）; the rate of adverse reactions like nausea, vomitting, decreasing leukocyte, decreasing blood platelet, diarrhea, and increasing bilirubin for two groups were not significantly different（P〉0.05）; within 1year, 2year and 3year, the survival rate of observation group was65.7%, 51.4% and 31.4%; within 1year, 2year and 3year, the survival rate of observation group was higher than that of control group（P〈0.05）.Conclusion The continuous TAI and TACE have a higher safety in patients with multiple hepatic metastasis focus, can efficiently control the development and proliferation of focus, relieve the clinical symptoms and improve the survival rate.

关 键 词：肝动脉灌注 栓塞治疗 TACE 肝脏多发转移性病灶 临床应用 

分 类 号：R657.3[医药卫生—外科学]