HLA基因多态性与严重药品不良反应相关性研究进展  

Research progress of correlation between HLA gene polymorphism and serious adverse drug reactions

作　　者：田雪梅[1,2] 马田甜[2] 王彦娥[2] 丁伶清 薛丹平 张美敬 房盛楠 王天宇[2] 余越[2] 林美钦[2] 宋洪涛[1] 

机构地区：[1]中国人民解放军南京军区福州总医院药学科,福建福州350025 [2]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016

出　　处：《中国新药与临床杂志》2016年第7期458-463,共6页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：随着遗传药理学的迅速发展,越来越多的研究发现人类白细胞抗原(HLA)基因多态性与药物引起不良反应之间存在一定的相关性。现有研究证实HLA-B等位基因与抗癫痫药物、氟氯西林、阿巴卡韦等引起严重皮肤不良反应的风险相关,麻醉药、抗癌药、抗生素、抗结核病药物、抗逆转录药物、强心剂等引起药源性肝损伤与HLA基因多态性也有一定的关联。为预防药品不良反应的发生,实施个体化给药方案,HLA基因多态性与药品不良反应发生间的相关性值得进一步研究。With the rapid development of pharmacogenetics, a growing number of studies found the correlations between human leukocyte antigen （HLA） gene polymorphisms and adverse drug reactions. Existing studies have confirmed the HLA -B alleles were related to the risk of serious skin reactions caused by antiepileptic, flucloxacillin, abacavir and so on. And the anesthetics, anticancer drugs, antibiotics, antituber- culotics, antiretroviral drugs, cardiotonic, etc cause drug-induced hepaticinjury and HLA gene polymorphisms have-a certain correlation. In order to prevent the occurrence of adverse drug reactions, the implementation of individualized administration, the correlation between HLA gene polymorphisms and adverse drug reactions is worth further study.

关 键 词：药物毒性 HLA抗原 多态性 单核苷酸 药品不良反应 

分 类 号：R595[医药卫生—内科学]