上海市黄浦区新生儿血源乙型肝炎疫苗免疫后28年效果随访  

Efficacy of Immunization of Plasma-derived Hepatitis B Vaccine 28 Years after Vaccination of Newborns in Huangpu District,Shanghai

作　　者：牟文[1] 周建军[1] 宿飞[1] 吴维寿[1] 汪萱怡[2] 姜铭波[1] 张国华[1] 

机构地区：[1]上海市黄浦区疾病预防控制中心,上海200023 [2]复旦大学生物医学研究院,上海200032

出　　处：《中国疫苗和免疫》2016年第3期278-280,277,共4页Chinese Journal of Vaccines and Immunization

基　　金：上海市黄浦区卫计系统学科带头人培养项目"黄浦区血源乙型肝炎疫苗免疫长期效果研究"(编号:HPXD-03)

摘　　要：目的了解新生儿血源乙型肝炎（乙肝）疫苗（HepB）接种的长期免疫效果和加强免疫的必要性。方法对黄浦区1986年出生并全程接种血源HepB的对象隔年随访,采血检测和分析乙肝表面抗原（HBs Ag）携带率、乙肝表面抗体（Anti-HBs）阳性率、乙肝核心抗体（Anti-HBc）阳性率。结果在28年14次随访的213~988例样本中,HBsAg携带率在0.19%~0.98%之间,未随免疫时间延长出现上升趋势（χ~2=0.870,P=0.351）;Anti-HBc阳性率在0.96%~3.40%之间,随免疫时间延长未呈现下降趋势（χ~2=3.457,P=0.063）;Anti-HBs阳性率在20.11%~89.72%之间,随免疫时间延长呈现下降趋势（χ~2=797.206,P〈0.001）。结论新生儿使用血源Hep B免疫有较好的持久性,免疫后28年无需加强免疫。Objective To evaluate the long-term effect of domestic plasma-derived hepatitis B vaccine（ p Hep B） in newborns,and to determine whether a booster dose is needed.Methods We followed up subjects who were born in 1986 and immunized with p Hep B in Huangpu district of Shanghai every two years,and determined carriage rates of hepatitis B surface antigen（ Hbs Ag） and positivity rates of hepatitis B surface antibody（ Anti-HBc） and hepatitis B core antibody（ Anti-HBc）.Results Among 213 of988 subjects receiving 14 follow-up assessments over 28-years,HBs Ag carriage rates were 0.19%-0.98%,without a significant increase over time（ χ~2= 0.870,P = 0.351）.Anti-HBc positive rates were0.96%-3.40% without a significant decrease over time（ χ~2= 3.457,P = 0.063）.Anti-HBs positive rates were 20.11%-89.72%,with a significant decrease over time（ χ~2= 797.206,P 0.001）.Conclusions The p Hep B had good immune persistence following vaccination of newborns.A booster immunization is not necessary 28 years after primary immunization.

关 键 词：血源乙肝疫苗 长期免疫效果 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]