聚4-乙烯基吡啶/羟基磷灰石纳米复合微粒的绿色制备及其药物缓释性能  

Preparation and characterization of poly(4-vinylpyridine)/hydroxyapatite composite in supercritical carbon dioxide

作　　者：郝有为 曹丽琴[1] 王吉德[1] 吴秀娟[1] 

机构地区：[1]新疆大学石油天然气精细化工教育部,自治区重点实验室,乌鲁木齐830046

出　　处：《化工新型材料》2016年第7期202-204,共3页New Chemical Materials

基　　金：国家自然科学基金资助项目(51263020)

摘　　要：在超临界二氧化碳分散体系中,借助于纳米尺寸为20nm的羟基磷灰石（HAP）中羟基的弱酸性,与聚4-乙烯基吡啶[P（4-VP）]中吡啶的弱碱性之间的弱酸碱作用,以偶氮二异丁腈（AIBN）为引发剂,诱导4-VP进行自由基聚合,制得了P（4-VP）/HAP纳米复合材料。考察了不同HAP含量、交联剂配比、不同反应温度、反应压力对产物形貌、产率的影响。最优制备方案为：0.100g AIBN,0.500g MBA,反应压力为19MPa,反应温度80℃,反应8h,产物粒径约1μm;溶胀率在pH=2-3时较高,SR=2.97。初步研究了P（4-VP）/HAP纳米复合材料对药物的缓释性能,通过调整环境pH值控制药物的缓释性能,pH=1.4时,在1h内药物释放基本完毕;在pH=7.8时,药物释放约3h,同时HAP聚合后的复合物的机械性能也得到了增强。In supercritical carbon dioxide dispersion system,hydroxyapatite（HAP）in size of 20 nm was mixed with4-vinyl pyridine.With the interaction between HAP＇s weak acid and 4-VP＇s alkalescence,poly（4-vinylpyridine）/hydroxyapatite nanocomposites were prepared via the radical initiated polymerization of 4-vinylpyridine using azobisisobutyronitrile（AIBN）as initiator.After the crosslinking reaction,the surface properties of nanocomposite and stability factor improved significantly.In order to optimize the reaction condition,the effects of reaction pressure,crosslinking agent HAP ratio,and reaction temperature on the grafting yield and morphology were investigated.Under the optimal synthesized condition：0.1g of AIBN,0.5g of MBA,reacted at 80℃ under a pressure of 19 MPa for 8h,loading of cytosine in the composite materials in scCO2,the properties of sustained release system was primarily investigated.The results revealed that the optimal synthesized condition lead to a higher yield,and the size was less than 1.0μm.The composites have a higher swelling ratio of 2.97 at pH 2-3at crosslinker ratio of 20.1%.Cytosine could be controlled release by changing external pH value condition.The composites exhibited a rapid release in solution of pH=1.4within 1h,and increased the pH to 7.8,cytosine need 3hto get release equilibrium.It behaved as effective drug carriers.The mechanical strength and thermal stability for the material were enhanced by adding inorganic materials of HAP.

关 键 词：聚乙烯基吡啶 羟基磷灰石 超临界二氧化碳 药物缓释 胞嘧啶 复合材料 

分 类 号：TB332[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]