中药治疗动脉硬化症伴脑梗死患者临床疗效观察  

Clinical effect of traditional Chinese medicine in the treatment of patients with atherosclerosis and cerebral infarction

作　　者：韦彤雁[1] 潘兴寿[1] 何思陆[1] 梁烨[1] 李清锋[1] 李天资[1] 邹才华[1] 李近都[2] 

机构地区：[1]右江民族医学院临床医学院,广西百色533000 [2]广西医科大学

出　　处：《中国医药科学》2016年第11期9-12,24,共5页China Medicine And Pharmacy

基　　金：国家自然科学基金(81060028);广西重大专项基金(桂科重1598005-9;1355005-3-7);广西卫生厅资助项目(GZZC1241;GZZC1242;GZZC1321;GZZC1323);广西百色市科技局基金资助项目(百科计20130104;20130106)

摘　　要：目的探讨益气活血通络治疗动脉粥样硬化伴脑梗死（AS＋CI）的疗效。方法对收治的80例AS＋CI患者随机分为治疗组和对照组,每组40例,对照组用常规疗法,治疗组在常规疗法的基础上用活血化瘀通络处方治疗30天,于治疗前后比较两组患者症状体征、纤溶功能（tPA、PAI）和血管内皮功能（ET、NO、PGI2）指标的改善情况,并与30例健康者比较。结果治疗组痊愈38例,显效1例,治愈率为96.5%;对照组痊愈36例,显效1例,治愈率为92.5%。两组疗效比较,差异无统计学意义（χ^2=0.355,P=0.522）;与健康者比较,治疗组与对照组患者tPA、PAI、ET、NO、PGI2水平治疗前均有异常改变（P〈0.01）,治疗组治疗后缓解至健康组水平（P〉0.05）,对照组只有NO水平治疗后缓解至健康组水平（P〉0.05）,tPA、PAI、ET、PGI2水平治疗后有所缓解,但与健康组比较差异仍有统计学意义（P〈0.01）;治疗组与对照组比较,治疗前两组患者ET、NO、PGI2水平比较差异无统计学意义（P〉0.05）,治疗后其差异有统计学意义（P〈0.01或P〈0.05）。结论益气活血通络可有效改善AS＋CI患者的血栓前状态和内皮功能紊乱状态,对预防AS恶化和脑梗死再发有积极的作用。Objective To explore the effect of supplementing qi and activating blood circulation therapy in the treatment of patients with atherosclerosis and cerebral infarction（AS＋CI）. Methods 80 AS＋CI patients who were in our hospital were randomly divided into treatment group and control group,40 cases in each group.The control group received routine therapy,the treatment group received a 30-day supplementing qi and activating blood circulation therapy based on routine treatment.The symptoms,fibrinolytic functions（tPA and PAI）,and blood vessel endothelium functions（ET,NO and PGI2） of the two groups before and after treatment were compared,and the indexes of all patients were compared with those of 30 healthy individuals（healthy group）. Results In the treatment group,there were 38 cases restored,1 case marked improvement,the cure rate was 96.5%,while in the control group,there were 36 cases restored,1 case marked improvement,the cure rate was 92.5%,the difference between the two groups was no statistically significant（χ^2=0.355,P=0.522）.Compared with healthy group,before treatment,the patients＇ tPA,PAI,ET,NO,and PGI2 in treatment and control groups were all abnormal（P〈0.01）,after treatment,these indexes in the treatment group relieved to normal levels（P〈0.05）,while in the control group,only the NO level relieved to normal level（P〈0.01）,the tPA,PAI,ET,and PGI2 levels relieved,but still had statistical differences with those of healthy group（P〈0.01）.Between treatment and control groups,before treatment,there were no statistical differences in patients＇ ET,NO,and PGI2（P〉0.05）,after treatment,there were statistical differences（P〈0.01 or P〈0.05）. Conclusion The supplement qi and activate blood circulation therapy can effectively improve the pre thrombotic states and endothelial dysfunctions in AS＋CI patients,and is positive in the prevention of AS deterioration and cerebral infarction recurrence.

关 键 词：活血化瘀通络 动脉粥样硬化 脑梗死 

分 类 号：R259[医药卫生—中西医结合]